抗致密细斑(DFS)抗体:间接免疫荧光染色模式及其临床意义。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-03-17 Print Date: 2022-03-01 DOI:10.2478/rjim-2021-0029
Samet Karahan, Şerife Emre, Hatice T Hörmet-Öz
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引用次数: 3

摘要

背景:密集细斑(DFS)模式是HEp-2间期细胞核质和中期细胞染色体区域非常强烈的异质斑点染色。评估Anti-DFS70与风湿病体征、症状和诊断的关系。方法:对2020年1 - 6月风湿病门诊连续收治的188例抗dfs70阳性患者进行分析。将抗dfs70抗体阳性的临床和实验室结果与DFS型ANA IFA染色率进行比较。回顾性分析1016例CTD患者抗dfs70阳性率及其与DFS染色模式的相关性。结果:77例(71.3%)患者以关节疼痛为主诉,10例(9.3%)dfs70阳性患者以rf阳性为实验室异常。最常见的ANA染色模式为DFS (72/108;66.7%);三分之一是DFS以外的。没有发现任何风湿病症状和实验室结果与DFS染色模式的关联有统计学意义。对964/1016例(94.88%)CTD患者进行ANA分析,其中抗dfs70阳性44例(4.56%)。相关系数显示DFS型染色与抗dfs70抗体阳性呈良好的相关性(r=+0.773, p)。结论:抗dfs70阳性CTD发生率低。CTD患者抗dfs70阳性率低。因此,可以认为anti-DFS70不能预测CTD,甚至排除CTD。
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Anti-dense fine speckled (DFS) antibody: its staining pattern in indirect immunofluorescence and its clinical relevance.

Background: Dense fine speckled (DFS) pattern is defined by very intense, heterogeneous speckled staining of nucleoplasms of interphase HEp-2 cells and chromosomal areas of metaphase cells. The association of Anti-DFS70 and rheumatologic signs, symptoms, and diagnosis were evaluated.Methods: One-hundred-eight anti-DFS70 positives who got consecutively admitted to the Rheumatology clinic between January and June 2020 were analyzed. The clinical and laboratory findings of positives for anti-DFS70 antibody were compared with those with DFS pattern ANA IFA staining rates. Also, anti-DFS70 positivity rates and their correlation with the DFS staining pattern were analyzed retrospectively in 1016 CTD patients.Results: The most common complaint was joint pain seen in 77 (71.3%) and the most common laboratory abnormality was RF-positivity observed in 10/108 (9.3%) who had anti-DFS70 positivity. The most common ANA staining pattern was DFS (72/108; 66.7%); one-third had other than DFS. No statistical significance was found for the association of any of the rheumatological complaints and laboratory findings with the DFS staining pattern. ANA analysis was performed in a total of 964/1016 (94.88%) CTD patients and 44 (4.56%) of these positive for anti-DFS70. The correlation coefficient showed good correlations between the DFS pattern staining and anti-DFS70 antibody positivity (r=+0.773, p<0.001).Conclusions: Anti-DFS70-positives have a low rate of CTD. A low anti-DFS70 positivity rate was observed in patients with CTD. As such, it can be considered that anti-DFS70 does not predict CTD or even excludes it.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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