B.1.1.7表面糖蛋白的系统发育性、新型距离功能及SARS-CoV-2表面糖蛋白V90T错义突变首次报道

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100967
Done Stojanov
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引用次数: 4

摘要

分析了截至2021年4月中旬欧洲向美国国家生物技术信息中心(NCBI)病毒数据库报告的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) B.1.1.7表面糖蛋白的系统发育性。为此,提出了计算系统发育距离的新函数。所提出的距离函数比Jaccard和Sorensen-Dice得到了更好的拟合聚类,并预测了B.1.1.7穗变异的准确进化联系。大多数B.1.1.7刺突变异在单个氨基酸变化上与其可能的直接前体有关,在许多情况下,这导致与更高的B.1.1.7 SARS-CoV-2传染性相关的关键突变丢失。也有引入第二种突变来弥补缺失突变的情况。还发现了未报道的V90T SARS-CoV-2表面糖蛋白突变,这有助于逃避2-51中和抗体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Phylogenicity of B.1.1.7 surface glycoprotein, novel distance function and first report of V90T missense mutation in SARS-CoV-2 surface glycoprotein

Phylogenicity of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 surface glycoproteins reported from Europe to the National Center for Biotechnology Information (NCBI) virus database by the mid of April 2021 is analyzed. Novel function for computing phylogenetic distance is proposed for that purpose. Proposed distance function resulted in better-fitted clusters than Jaccard and Sorensen-Dice and accurate evolutionary links were predicted for B.1.1.7 spike variants. Most B.1.1.7 spike variants were linked to their likely direct predecessors at single amino acid change, that in many cases resulted in loss of the key mutations that are associated to the higher B.1.1.7 SARS-CoV-2 infectivity. There were also cases where second mutation was introduced to compensate for the missing mutation. Unreported V90T SARS-CoV-2 surface glycoprotein mutation was also identified, that contributes towards escaping 2–51 neutralizing antibody.

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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
期刊最新文献
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