XRN2 和 XTBD 家族蛋白对核 RNA 的调控

IF 2 4区生物学 Q4 CELL BIOLOGY Cell structure and function Pub Date : 2021-11-06 Epub Date: 2021-09-03 DOI:10.1247/csf.21041

Ilkin Aygün, Takashi S Miki

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引用次数: 0

摘要

XRN2是一种5'到3'的外核糖核酸酶，主要定位于细胞核。通过降解或修剪各种类型的RNA, XRN2有助于基因表达的必要过程，如转录终止和核糖体生物发生。尽管体外底物特异性有限，但XRN2通过与细胞中的其他蛋白质相互作用靶向特定的RNA亚群。本文综述了具有进化上保守的xrn2结合结构域XTBD的蛋白质的功能。这些蛋白通过稳定XRN2，控制其亚细胞定位或将其招募到特定的RNA靶标来调节XRN2的活性，从而影响各种细胞过程。关键词:RNA调控，XRN2, XTBD，核糖体生物发生，亚细胞定位

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Nuclear RNA Regulation by XRN2 and XTBD Family Proteins.

XRN2 is a 5'-to-3' exoribonuclease that is predominantly localized in the nucleus. By degrading or trimming various classes of RNA, XRN2 contributes to essential processes in gene expression such as transcription termination and ribosome biogenesis. Despite limited substrate specificity in vitro, XRN2 targets a specific subset of RNA by interacting with other proteins in cells. Here we review the functions of proteins that have an evolutionarily conserved XRN2-binding domain, XTBD. These proteins modulate activity of XRN2 by stabilizing it, controlling its subcellular localization or recruiting it to specific RNA targets, and thereby impact on various cellular processes.Key words: RNA regulation, XRN2, XTBD, ribosome biogenesis, subcellular localization.

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来源期刊

Cell structure and function 生物-细胞生物学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cell Structure and Function is a fully peer-reviewed, fully Open Access journal. As the official English-language journal of the Japan Society for Cell Biology, it is published continuously online and biannually in print. Cell Structure and Function publishes important, original contributions in all areas of molecular and cell biology. The journal welcomes the submission of manuscripts on research areas such as the cell nucleus, chromosomes, and gene expression; the cytoskeleton and cell motility; cell adhesion and the extracellular matrix; cell growth, differentiation and death; signal transduction; the protein life cycle; membrane traffic; and organelles.