日本母马外阴鳞状细胞癌与马蹄乳头瘤病毒2型感染相关

IF 4.7 Q1 VIROLOGY Tumour Virus Research Pub Date : 2021-12-01 DOI:10.1016/j.tvr.2021.200226
Nanako Yamashita-Kawanishi , Soma Ito , James K. Chambers , Kazuyuki Uchida , Masato Sato , Hui Wen Chang , Cameron Knight , Frank van der Meer , Takeshi Haga
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引用次数: 3

摘要

马阴道乳头瘤病毒2型(EcPV2)感染与马生殖器鳞状细胞癌(SCC)的发展有关。然而,在亚洲很少有关于ecpv2相关疾病的报道。我们研究了日本母马ecpv2相关外阴SCC的病理和病毒学特征。常规PCR、原位杂交、逆转录酶PCR和免疫组织化学证实了EcPV2在病变内的存在和分布,提示p53降解可能不是该病毒诱导肿瘤转化的机制。日本病例的完整病毒序列显示与欧洲EcPV2参考株的序列同源性接近完美,这在考虑未来EcPV2疫苗开发的目标时可能有用。该报告还强调了EcPV2在女性(外阴)肿瘤中的重要性,这比EcPV2诱导的男性(阴茎或包皮)肿瘤更不常见。最后,在这匹母马中描述的SCC是一种不寻常的棘溶性变异,以前没有在马中报道过。这是亚洲首例从生殖器鳞状细胞癌中发现EcPV2的报告,并强调了该病毒可能在世界范围内的分布及其与马生殖器瘤变的一致关联。
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Vulvar squamous cell carcinoma associated with Equus caballus papillomavirus type 2 infection in a Japanese mare

Equus caballus papillomavirus type 2 (EcPV2) infection has been associated with genital squamous cell carcinoma (SCC) development in horses. However, very few reports on EcPV2-associated disease in Asia exist. Our study characterizes pathological and virological features of an EcPV2-associated vulvar SCC from a Japanese mare. Conventional PCR, in situ hybridization, reverse-transcriptase PCR and immunohistochemistry confirmed the presence and distribution of EcPV2 within the lesion and suggested that p53 degradation may not be the mechanism by which this virus induces neoplastic transformation. The complete viral sequence in this Japanese case shows near perfect sequence homology with European reference strains of EcPV2, which may be useful when considering the target for future EcPV2 vaccine development. This report also serves to highlight the importance of EcPV2 in female (vulvar) neoplasia, which is less commonly recognized than EcPV2-induced male (penile or preputial) neoplasia. Finally, the SCC described in this mare was an unusual acantholytic variant that has not been reported previously in horses. It is the first report of EcPV2 identified from genital SCC in Asia and underscores the likely worldwide distribution of this virus and its consistent association with equine genital neoplasia.

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来源期刊
Tumour Virus Research
Tumour Virus Research Medicine-Infectious Diseases
CiteScore
6.50
自引率
2.30%
发文量
16
审稿时长
56 days
期刊最新文献
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