在一项基于人群的研究中,血清一氧化氮水平与甲状腺功能测试变化之间的关系:德黑兰甲状腺研究参与者(TTS)。

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM International Journal of Endocrinology and Metabolism Pub Date : 2021-03-28 eCollection Date: 2021-07-01 DOI:10.5812/ijem.109214
Behnaz Ghazisaeidi, Farzaneh Sarvghadi, Asghar Ghasemi, Maryam Tohidi, Fereidoun Azizi, Atieh Amouzegar
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引用次数: 1

摘要

背景:一氧化氮(NO)通过抑制甲状腺碘化钠同调体(NIS)对碘(I)的摄取以及对甲状腺血管和血流的影响,在甲状腺功能调节中起关键作用。目的:本研究旨在探讨血清NO代谢物(NOx)与促甲状腺激素(TSH)、游离甲状腺素(FT4)、抗甲状腺过氧化物酶(TPOAb)变化的关系。同时,通过3年的随访,评估血清NOx与临床甲状腺功能减退(以TSH水平升高、FT4浓度降低为特征)和亚临床甲状腺功能减退(以FT4浓度在正常范围内但TSH水平轻度升高为特征)发生率的相关性。方法:本研究纳入了德黑兰甲状腺研究(TTS)的1137名年龄> 20岁的参与者,他们在第三期和第四期的血清TSH、FT4和TPOAb以及第三期的血清NOx数据。计算第三期和第四期TSH (ΔTSH)、FT4 (ΔFT4)和TPOAb (ΔTPO)的变化,并通过线性回归分析进行多变量调整后评估血清NOx与ΔTSH、ΔFT4和ΔTPOAb的相关性。结果:经多变量调整后,血清NOx与ΔTSH、ΔFT4、ΔTPOAb无显著相关性;经多变量校正后,TPOAb分裂组均未见异常。血清NOx含量与TTS第四期临床和亚临床甲状腺功能减退发生率无显著相关性。结论:血清NOx水平与TSH、FT4和TPOAb的变化与临床和亚临床甲状腺功能减退发病率无相关性。
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Association Between Serum Nitric Oxide Level and Changes in Thyroid Function Test in a Population-based Study: Tehran Thyroid Study Participants (TTS).

Background: Nitric oxide (NO) plays a key role in thyroid function regulation through the inhibition of iodide (I) uptake at the thyroidal sodium-iodide symporter (NIS) and impacts on the thyroid vascularity and blood flow.

Objectives: This study aimed to evaluate the association between serum NO metabolites (NOx) and thyroid-stimulating hormone (TSH), free thyroxin (FT4), and anti-thyroid peroxidase (TPOAb) changes. Also, it aimed at evaluating the correlation between serum NOx and the incidence of clinical hypothyroidism, characterized by elevated TSH level and decreased FT4 concentration, and subclinical hypothyroidism, characterized by mildly elevated TSH level despite FT4 concentration within the normal range, over three years of follow-up.

Methods: This study included 1,137 participants of the Tehran Thyroid study (TTS), aged > 20 years old, for whom data on serum TSH, FT4, and TPOAb in the third and fourth phases, and serum NOx in the third phase were available. Changes in TSH (ΔTSH), FT4 (ΔFT4), and TPOAb (ΔTPO) between the third and fourth phases were calculated, and the associations between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb were assessed after multivariable adjustment using linear regression analysis.

Results: No significant association was found between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb after the multivariable adjustment; neither was any observed in TPOAb split groups after multivariable adjustment. No significant association was found between serum NOx tertiles and clinical and subclinical hypothyroidism incidence in the fourth phase of TTS.

Conclusions: There was no association between serum NOx levels and changes in TSH, FT4, and TPOAb and clinical and subclinical hypothyroidism incidence.

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期刊介绍: The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.
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