维生素D受体基因变异、血浆25-羟基维生素D与经前症状的风险

Alicia C Jarosz, Daniel Noori, Tara Zeitoun, Bibiana Garcia-Bailo, Ahmed El-Sohemy
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引用次数: 3

摘要

背景:在一些研究中,维生素D水平与几种经前症状(PMSx)的存在和严重程度有关,但不是全部。这些发现之间的不一致可能是由于维生素D受体(VDR)的遗传变异未被解释。目的:确定VDR基因型是否影响维生素D水平与个体PMSx之间的关系。方法:来自多伦多营养基因组学与健康研究的716名年龄在20-29岁的女性提供了血浆样本,并完成了一份关于15种常见PMSx存在和严重程度的问卷调查。测定血浆25-羟基维生素D (25(OH)D)浓度,并将参与者分为维生素D充足(≥50 nmol/L)组和维生素D不足(< 50 nmol/L)组。从血液样本中获得DNA,对常见的VDR单核苷酸变异rs796858进行基因分型。使用逻辑回归,比较维生素d充足和不足的妇女之间经历PMSx的几率,按基因型分层。结果:在CC纯合子中,维生素D状态不足与经历经前疲劳的几率较高相关(OR, 2.53;95% CI, 1.40, 4.56)和恶心(OR, 2.44;95% ci, 1.00, 5.95)。在TT纯合子中,维生素D状态不足与较低的疲劳发生率相关(OR, 0.44;95% CI, 0.20, 0.97)和食欲增加(OR, 0.48;95% ci, 0.22, 1.04)。维生素D不足与CT基因型女性食欲增加的几率较高相关(OR, 1.78;95% ci, 1.03, 3.07)。VDR基因型改变了维生素D状态与以下PMSx之间的关系:食欲增加(相互作用p = 0.027)、疲劳(相互作用p = 0.016)和恶心(相互作用p = 0.039)。结论:我们发现VDR基因型可能改变25(OH)D与某些PMSx的关系。25(OH)D不足与CC基因型患者经前疲劳风险较高相关,而TT基因型患者经前疲劳风险较低。
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Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms.

Background: Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic variation in the vitamin D receptor (VDR).

Objective: To determine whether associations between vitamin D status and individual PMSx are influenced by VDR genotype.

Methods: Seven hundred sixteen women aged 20-29 years old from the Toronto Nutrigenomics and Health study provided plasma samples and completed a questionnaire on the presence and severity of 15 common PMSx. Plasma 25-hydroxyvitamin D (25(OH)D) concentration was measured and participants were categorized into sufficient (≥ 50 nmol/L) and insufficient (< 50 nmol/L) vitamin D status groups. DNA was obtained from blood samples to genotype for a common VDR single nucleotide variant, rs796858. Using logistic regression, odds of experiencing PMSx were compared between vitamin D-sufficient and insufficient women, stratified by genotype.

Results: Among CC homozygotes, insufficient vitamin D status was associated with higher odds of experiencing premenstrual fatigue (OR, 2.53; 95% CI, 1.40, 4.56) and nausea (OR, 2.44; 95% CI, 1.00, 5.95). Among TT homozygotes, insufficient vitamin D status was associated with lower odds of experiencing fatigue (OR, 0.44; 95% CI, 0.20, 0.97) and increased appetite (OR, 0.48; 95% CI, 0.22, 1.04). Insufficient vitamin D status was associated with higher odds of increased appetite in women with the CT genotype (OR, 1.78; 95% CI, 1.03, 3.07). VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039).

Conclusion: We found evidence that VDR genotype may modify the association between 25(OH)D and some PMSx. Insufficient 25(OH)D was associated with a higher risk of premenstrual fatigue in those with the CC genotype, but lower risk in those with the TT genotype.

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