全球消除乙型肝炎的前景。

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2021-09-29 DOI:10.1146/annurev-virology-091919-062728
Timothy M Block, Kyong-Mi Chang, Ju-Tao Guo
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引用次数: 17

摘要

慢性乙型肝炎病毒(HBV)感染是导致肝硬化和肝细胞癌的主要原因,估计每年在全球造成约80万人死亡。虽然有有效的疫苗可以预防新的HBV感染,但对现有慢性乙型肝炎(CHB)的治疗是有限的,因为目前的标准治疗抗病毒药物只能抑制病毒复制而不能治愈。2016年,世界卫生组织呼吁到2030年消除病毒性肝炎这一全球公共卫生威胁。美国和其他国家正在努力通过制定治疗慢性乙型肝炎和预防乙型肝炎传播的战略来实现这一雄心勃勃的目标。本文综述了近年来在了解HBV病理生物学和治疗慢性乙型肝炎方面的研究进展,这是到2030年消除乙型肝炎所必需的。
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Prospects for the Global Elimination of Hepatitis B.

Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and hepatocellular carcinoma, estimated to be globally responsible for ∼800,000 deaths annually. Although effective vaccines are available to prevent new HBV infection, treatment of existing chronic hepatitis B (CHB) is limited, as the current standard-of-care antiviral drugs can only suppress viral replication without achieving cure. In 2016, the World Health Organization called for the elimination of viral hepatitis as a global public health threat by 2030. The United States and other nations are working to meet this ambitious goal by developing strategies to cure CHB, as well as prevent HBV transmission. This review considers recent research progress in understanding HBV pathobiology and development of therapeutics for the cure of CHB, which is necessary for elimination of hepatitis B by 2030.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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