Y L Wong, C P W Cheng, C S M Wong, S N Wong, H L Wong, S Tse, G H Y Wong, W C Chan
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引用次数: 5
摘要
目的:我们旨在对认知刺激(CS)对痴呆患者的认知、抑郁症状和生活质量的影响进行最新的系统回顾和荟萃分析。考察了影响治疗效果的因素。方法:检索截至2019年3月7日的MEDLINE、EMBASE、PsycINFO、CINAHL Plus和Cochrane Library数据库的文献。仅纳入了调查CS对痴呆患者影响的随机对照试验。结果测量是认知功能、抑郁症状和生活质量。结果:20项随机对照试验，共1251名受试者(干预组:674名;对照组577例)纳入meta分析。大多数参与者患有轻度至中度痴呆症。CS对认知有显著的小到中等的正影响(Hedges’s g = 0.313, p < 0.001)。CS的异质性为中低(Q=30.5854, df=19, p < 0.05, I2 = 37.877%)。抑郁症状与生活质量之间的关系尚无定论。结论:CS对认知功能有显著的积极作用，但对抑郁症状和生活质量的影响尚无定论。未来的研究需要更有力的方法来确定其有效性的证据。
Cognitive Stimulation for Persons with Dementia: a Systematic Review and Meta-Analysis.
Objective: We aim to provide an up-to-date systematic review and meta-analysis of the effects of cognitive stimulation (CS) on cognition, depressive symptoms, and quality of life in persons with dementia. Factors affecting the treatment effect were examined.
Methods: A literature search was performed on databases of MEDLINE, EMBASE, PsycINFO, CINAHL Plus, and Cochrane Library up to 7 March 2019. Only randomised controlled trials investigating the effects of CS in persons with dementia were included. The outcome measures were cognitive function, depressive symptoms, and quality of life.
Results: 20 randomised controlled trials with a total of 1251 participants (intervention group: 674; control group: 577) were included for meta-analysis. Most participants had mild to moderate dementia. CS had a significant positive small-to-moderate effect on cognition (Hedges's g = 0.313, p < 0.001). Heterogeneity of CS was low to moderate (Q=30.5854, df=19, p < 0.05, I2 = 37.877%). Inconclusive results were found for depressive symptoms and quality of life.
Conclusion: CS has a significant positive effect on cognitive function, but its effect on depressive symptoms and quality of life was inconclusive. Future studies with more robust methodology establishing evidence of its efficacy are required.
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