两种辅助通气镇静方案对健康新生马驹心肺效果和恢复特征的影响。

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-10-01
Carolyn L Kerr, Stephanie C J Keating, Luis G Arroyo, Laurent Viel
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引用次数: 0

摘要

新生马驹可能需要长时间的镇静,以便在生命的最初几天进行呼吸支持。本研究的目的是评估和比较两种镇静/镇痛方案对接受辅助通气的健康马驹的心肺效果和临床恢复特征。马驹在24小时内随机接受右美托咪定、丁托啡诺和异丙酚(DBP)或咪达唑仑、丁托啡诺和异丙酚(MBP)治疗。调整右美托咪定、咪达唑仑和异丙酚的输注速率,并根据设定的方案给药异丙酚,以保持最佳的镇静和肌肉松弛。将通气支持变量调整到预设目标。记录生理变量,测量心输出量(CO)(热稀释),并每隔24小时收集动脉血和混合静脉血进行气体分析。DBP组马驹给予右美托咪定[2.4±0.5 μg/kg体重(BW) /小时]、丁托啡诺(13 μg/kg体重/小时)、异丙酚(6.97±0.86 mg/kg体重/小时),MBP组马驹给予咪达唑仑(0.14±0.04 mg/kg体重/小时)、丁托啡诺(13 μg/kg体重/小时)、异丙酚(5.98±1.33 mg/kg体重/小时)。DBP组马驹接受的异丙酚剂量(9.0±3.0)明显高于MBP组(4.0±2.0)。虽然生理变量仍在可接受范围内,但DBP组马驹的心率(HR)、平均动脉压(MAP)和心脏指数(CI)低于MBP组。DBP组到胸骨卧位、站立和护理的时间明显短于MBP组。我们发现MBP和DBP方案适合辅助新生儿马驹的呼吸支持,尽管与DBP相比,MBP会导致更长的恢复时间。
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Cardiopulmonary effects and recovery characteristics associated with 2 sedative protocols for assisted ventilation in healthy neonatal foals.

Neonatal foals may require prolonged sedation to permit ventilatory support in the first few days of life. The objective of this study was to evaluate and compare the cardiopulmonary effects and clinical recovery characteristics of 2 sedative/analgesia protocols in healthy foals receiving assisted ventilation. Foals were randomized to receive dexmedetomidine, butorphanol, and propofol (DBP) or midazolam, butorphanol, and propofol (MBP) during a 24-hour period. Infusion rates of dexmedetomidine, midazolam, and propofol were adjusted and propofol boluses administered according to set protocols to maintain optimal sedation and muscle relaxation. Ventilatory support variables were adjusted to preset targets. Physiologic variables were recorded, cardiac output (CO) measured (thermodilution), and arterial and mixed venous blood collected for gas analysis at intervals up to 24 hours. Foals in group DBP received dexmedetomidine [2.4 ± 0.5 μg/kg body weight (BW) per hour], butorphanol (13 μg/kg BW per hour), and propofol (6.97 ± 0.86 mg/kg BW per hour), whereas foals in group MBP received midazolam (0.14 ± 0.04 mg/kg BW per hour), butorphanol (13 μg/kg BW per hour), and propofol (5.98 ± 1.33 mg/kg BW per hour). Foals in the DBP group received significantly more propofol boluses (9.0 ± 3.0) than those in the MBP group (4.0 ± 2.0). Although physiologic variables remained within acceptable limits, heart rate (HR), mean arterial pressure (MAP), and cardiac index (CI) were lower in foals in the DBP group than in the MBP group. Times to sternal recumbency, standing, and nursing were significantly shorter in the DBP than MBP group. We found that MBP and DBP protocols are suitable to assist ventilatory support in neonatal foals, although MBP results in a prolonged recovery compared to DBP.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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