子宫积脓犬卵巢子宫切除术前后临床及炎症参数的比较。

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-10-01
Soomin Ahn, Hyeona Bae, Jihu Kim, Suhee Kim, Jinho Park, Sang-Ki Kim, Dong-In Jung, DoHyeon Yu
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引用次数: 0

摘要

本研究旨在确定犬脓脓症的潜在生物标志物及其与临床参数的相关性。首先,将90只脓膜增生犬与26只健康母犬进行比较。然后,对22只脓膜瘤犬和9只健康对照犬的配对样本(卵巢子宫切除术前后)进行比较。脓脓狗的急性炎症蛋白、c反应蛋白(CRP)、血清淀粉样蛋白A (SAA)和无细胞DNA (cfDNA)浓度显著高于临床健康狗。根据受试者工作特征曲线分析(曲线下面积= 0.959),无细胞DNA是全身性炎症最敏感的生物标志物。此外,cfDNA和CRP与炎症和器官损伤相关的临床参数显著相关。手术切除发炎子宫后,白细胞介素-6 (IL-6)、高迁移率组盒1 (HMGB1)和降钙素原(PCT)显著降低,而CRP、SAA和cfDNA的变化不显著。这些发现表明cfDNA、CRP和SAA是脓脓症犬全身炎症的潜在临床生物标志物,PCT、IL-6和HMGB1是临床恢复的潜在生物标志物。
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Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy.

This study aimed to identify potential biomarkers of canine pyometra and their correlations with clinical parameters. First, 90 dogs with pyometra and 26 healthy female dogs were compared. Then, paired samples (before and after ovariohysterectomy) from 22 dogs with pyometra and 9 healthy controls from the initial cohort were compared. Concentrations of acute inflammatory proteins, C-reactive protein (CRP) and serum amyloid A (SAA), and cell-free DNA (cfDNA), were significantly higher in dogs with pyometra than in clinically healthy dogs. Cell-free DNA was the most sensitive biomarker for systemic inflammation, based on the receiver operating characteristic curve analysis (area under the curve = 0.959). In addition, cfDNA and CRP were significantly associated with inflammation and organ injury-related clinical parameters. Following the surgical removal of the inflamed uterus, interleukin-6 (IL-6), high-mobility group box 1 (HMGB1), and procalcitonin (PCT) significantly decreased, whereas changes in CRP, SAA, and cfDNA were not significant. These findings indicate that cfDNA, CRP, and SAA are potential clinical biomarkers of systemic inflammation in dogs with pyometra and PCT, IL-6, and HMGB1 are potential biomarkers of clinical recovery.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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