{"title":"冠状动脉粥样硬化患者循环血管紧张素- iii水平及意义。","authors":"Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang","doi":"10.1155/2021/1704762","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).</p><p><strong>Methods and results: </strong>Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (<i>P</i> = 0.013). APA levels were slightly lower in the CAS group (<i>P</i> = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.</p><p><strong>Conclusions: </strong>Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.</p>","PeriodicalId":17330,"journal":{"name":"Journal of the Renin-Angiotensin-Aldosterone System","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478585/pdf/","citationCount":"1","resultStr":"{\"title\":\"The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.\",\"authors\":\"Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang\",\"doi\":\"10.1155/2021/1704762\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).</p><p><strong>Methods and results: </strong>Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (<i>P</i> = 0.013). APA levels were slightly lower in the CAS group (<i>P</i> = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.</p><p><strong>Conclusions: </strong>Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.</p>\",\"PeriodicalId\":17330,\"journal\":{\"name\":\"Journal of the Renin-Angiotensin-Aldosterone System\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2021-09-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478585/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Renin-Angiotensin-Aldosterone System\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2021/1704762\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Renin-Angiotensin-Aldosterone System","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2021/1704762","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 1
摘要
目的:血管紧张素- iii (angiotentin - iii, Ang-III)是氨基肽酶A (APA)代谢血管紧张素- ii (Ang-II)的下游产物。目前对Ang-III的研究主要集中在高血压和中枢肾素-血管紧张素系统(RAS)方面。然而，很少有研究关注Ang-III与冠状动脉粥样硬化(CAS)的关系。方法与结果:采用酶联免疫吸附试验(ELISA)测定44例正常人和84例经冠状动脉造影确诊的CAS患者血浆Ang-III和APA水平。CAS患者的循环Ang-III水平明显低于正常对照组(P = 0.013)。CAS组APA水平稍低(P = 0.324)。根据动脉粥样硬化的严重程度将CAS患者分为两组。与对照组相比，高评分组APA和Ang-III水平较低，且APA显著降低。结论:CAS患者循环Ang-III水平降低，可能与APA水平降低有关。
The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.
Objective: Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).
Methods and results: Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (P = 0.013). APA levels were slightly lower in the CAS group (P = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.
Conclusions: Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.
期刊介绍：
JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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