聚谷氨酸接枝多巴胺改性胶原-聚乙烯醇水凝胶,可用于伤口敷料。

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2021-09-28 eCollection Date: 2021-01-01 DOI:10.1080/15685551.2021.1984007
Guofei Yu, Changkai Yang, Nianhua Dan, Weihua Dan, Yining Chen
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引用次数: 0

摘要

天然胶原蛋白具有良好的生物相容性和促进组织再生与修复的能力,但天然胶原蛋白机械性能差、不耐降解,限制了其在生物医学领域的应用。在这项研究中,我们合成了一种具有良好生物活性、高强度和优异吸水性能的皮肤伤口修复水凝胶。受到湿性愈合理论的启发,我们在吸水聚合物聚谷氨酸的侧链中引入多巴胺,合成了一种兼具吸水性和细胞粘附性的交联剂(PGAD),然后将其引入胶原蛋白/聚乙烯醇(PVA-COL)体系中,形成双网络水凝胶。对水凝胶形态特征的扫描电子显微镜观察表明,引入 PGAD 后,水凝胶形成了明显的孔隙结构,膨胀率表明,引入 PGAD 显著提高了水凝胶的吸水率。体内伤口愈合实验表明,水凝胶可以促进伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Polyglutamic acid grafted dopamine modified collagen-polyvinyl alcohol hydrogel for a potential wound dressing.

Natural collagen has good biocompatibility and ability to promote tissue regeneration and repair, but the poor mechanical properties and intolerance of degradation of natural collagen limit its applications in the biomedical field. In this research, we synthesized a skin wound repair hydrogel with good biological activity, high strength and excellent water absorption properties. Inspired by the theory of wet healing, dopamine was introduced into the side chain of the water-absorbing polymer polyglutamic acid to synthesize a cross-linking agent (PGAD) with both water absorption and cell adhesion ablities, and then it was introduced into collagen/polyvinyl alcohol (PVA-COL) system to form a double network hydrogel. Scanning electron microscope observation of the morphological characteristics of the hydrogel showed that after the introduction of PGAD, the hydrogel formed an obvious pore structure, and the swelling rate showed that the introduction of PGAD significantly improved the water absorption rate of the hydrogel.In addition, PVA-COL-PGAD hydrogel has good mechanical properties and water absorption behavior.In vitro experimental results revealed that the hydrogel has good biocompatibility. In vivo wound healing experiments showed that hydrogel can promote wound healing process.These results indicated that our hydrogel has great potential as a medical wound dressing.

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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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