[Epithelioid angiomyolipoma of the kidney after successfully treated malignant melanoma].

Background: Therapy of epitheloid angiomyolipomas (eAML) may be challenging, since unlike classical angiomyolipomas this rare subclass of benign mesenchymal angiomyolipomas may present with lymph node metastases, local recurrent disease, and/or systemic metastatic disease in up to 30% of cases.

Objectives: We report here for the first time in Germany a case of eAML after successful treatment of malignant melanoma.

Materials and methods: Clinical and histological findings as well as results of the genetic analysis of the angiomyolipoma are presented.

Results: A somatic, truncating mutation of the TSC2 gene was found in the angiomyolipoma.

Conclusion: The relationship to histologically similar tumor entities are presented and therapeutic options based on the genetic classification are discussed.