是的,老妈!

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2021-05-19 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1919473

Robert E Means, Samuel G Katz

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引用次数: 9

摘要

BCL-2蛋白家族成员对细胞生死的调控发生在线粒体。线粒体外膜的大部分与内质网(ER)紧密接近，称为线粒体相关膜(MAMs)或线粒体-内质网接触点(MERCs)。我们最近报道了BOK存在于MAM中，它调节Ca2+从内质网转移到线粒体，适当的MAM成分和MERC结构以及细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Yes, MAM!

Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria's outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mitochondria-associated membranes (MAMs) or mitochondria-ER contact sites (MERCs). We recently reported that BOK is present within MAMs where it regulates Ca²⁺ transfer from the ER to the mitochondria, appropriate MAM components and MERC structure, and apoptosis.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.