TFG:一种新的ulk1依赖性自噬调节因子。

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2021-07-12 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1945895

Francesco Cecconi, Francesca Nazio

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引用次数: 0

摘要

trk融合基因(TFG)是一种涉及多种神经退行性疾病和肿瘤发生的蛋白。我们最近的研究表明，在饥饿条件下，TFG通过促进Unc-51样自噬激活激酶1 (ULK1)-微管相关蛋白1轻链3 γ (MAP1LC3C)相互作用来调节大体和自噬体的形成，从而有助于自噬的空间控制。因此，有缺陷的tfg介导的自噬可以被假设为tfg相关疾病的个体发生或进展的可能因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TFG: a novel regulator of ULK1-dependent autophagy.

TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.