淋巴内皮细胞异质性研究综述。

IF 5 3区医学 Q2 IMMUNOLOGY Inflammation and Regeneration Pub Date : 2021-10-11 DOI:10.1186/s41232-021-00183-6

Masayuki Miyasaka

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引用次数: 1

摘要

最近在小鼠和人类中进行的单细胞RNA测序研究清楚地表明，淋巴内皮细胞(LECs)由多个细胞亚群组成，每个细胞亚群表达一组独特的基因，位于体内不同的位置。这些研究还揭示了动物LECs中基因表达的保守模式，以及每个物种特有的特殊基因集。然而，这种异质性在多大程度上适应LECs周围的外部环境仍不清楚。编程LECs不同亚群的转录和调控途径也仍未被探索。

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A short review on lymphatic endothelial cell heterogeneity.

Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as well as specialized sets of genes unique to each species. However, the extent to which this heterogeneity is adaptive to the external milieu surrounding LECs has remained unclear. The transcriptional and regulatory pathways that program the different subsets of LECs also remain unexplored.

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.