侵袭性微乳头状乳腺癌中半乳糖凝集素-3在肿瘤及癌相关成纤维细胞中的表达:与临床病理参数的关系

European journal of breast health Pub Date : 2021-10-04 eCollection Date: 2021-10-01 DOI:10.4274/ejbh.galenos.2021.2021-2-8
Yasemin Çakır, Canan Kelten Talu, Özlem Mermut, Didem Can Trabulus, Esra Arslan
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引用次数: 1

摘要

目的:半乳糖凝集素-3通过在肿瘤和癌相关成纤维细胞(CAFs)中表达影响肿瘤进展和细胞表面极化。因此,它可能对具有独特形态学特征的微乳头状癌(IMPC)有作用。目的是研究半乳糖凝集素-3在IMPC肿瘤和瘤周CAFs中的表达水平,并与侵袭性导管癌(IDC)中的表达进行比较。材料与方法:对2010-2016年检查的苏木精和伊红染色的切除材料进行重新评价。比较34例与IMPC分子亚型分布相似的IMPC和34例IDC病例。半凝集素-3水平在肿瘤中以计算的h评分进行评估,在CAFs中以半定量的方式进行评估。结果:尽管肿瘤中半乳糖凝集素-3的表达水平在IMPCs中高于IDCs,但两种组织学类型的CAFs中半乳糖凝集素-3的表达没有差异。然而,在IMPCs中,肿瘤中Galectin-3的表达与临床病理参数无显著关系。当受试者被分为两组时,根据他们的半乳糖凝集素-3状态而不考虑组织学类型,发现半乳糖凝集素-3在肿瘤中的表达缺失与肿瘤大小较大/ pT分期晚期和转移淋巴结数量较多有关。此外,发现半乳糖凝集素-3在CAFs中的表达与远处转移有关。结论:与IDC相比,imc肿瘤中Galectin-3表达显著。然而,与组织学类型无关,肿瘤中半乳糖凝集素-3表达的缺失与肿瘤大小和转移性腋窝淋巴结数量的增加有关,而cas中半乳糖凝集素-3表达的存在与远处转移有关。
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The Expression of Galectin-3 in Tumor and Cancer-Associated Fibroblasts in Invasive Micropapillary Breast Carcinomas: Relationship with Clinicopathologic Parameters.

Objective: Galectin-3 affects tumor progression and cell surface polarization by expressing from the tumor and cancer-associated fibroblasts (CAFs). Therefore, it may have a role on micropapillary carcinomas (IMPC), which have characteristic morphological features. The aim was to investigate the expression levels of Galectin-3 within tumor and peritumoral CAFs in IMPC, and to compare with expression in invasive ductal carcinomas (IDC).

Materials and methods: Hematoxylin and Eosin-stained preparations of resection materials examined between 2010-2016 were re-evaluated. Thirty-four IMPC cases and 34 IDC cases with similar molecular subtype distribution to IMPC were compared. Galectin-3 levels were evaluated with a calculated H-score in tumor and semi-quantitatively in CAFs.

Results: While tumoral Galectin-3 expression levels were higher in IMPCs compared to IDCs, there was no difference for Galectin-3 expression in CAFs between the two histologic types. However, there was no significant relationship between tumoral Galectin-3 expression and clinicopathological parameters in IMPCs. When the subjects were divided into two groups, depending on their Galectin-3 status regardless of histological types, the loss of Galectin-3 expression in tumor was found to be related to larger tumor size/advanced pT stage and a greater number of metastatic nodes. Additionally, expression of Galectin-3 in CAFs was found to be associated with distant metastasis.

Conclusion: IMPC showed prominent Galectin-3 expression in tumor compared to IDC. However, independent from the histological type, whereas the loss of Galectin-3 expression in tumor showed an association with larger tumor size and higher number of metastatic axillary lymph nodes, the presence of Galectin-3 expression in CAFs showed an association with distant metastasis.

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