Hiba Alzoubi, Francesca Gianno, Yussuf Abuelhaija, Angam Ayyoub Najadat, Ahmad Mustafa, Aws Younes Al-Arman, Lujain Younes Al-Arman, Dana Banihani, Aya Mustafa, Noor Abualdahab, Giuseppe Broggi, Gabriele Gaggero, Nataniele Piol, Pietro Fiaschi, Evelina Miele, Felice Giangaspero
{"title":"老年患者小脑脂质神经细胞瘤:DNA甲基化分析作为一种有用的诊断工具。","authors":"Hiba Alzoubi, Francesca Gianno, Yussuf Abuelhaija, Angam Ayyoub Najadat, Ahmad Mustafa, Aws Younes Al-Arman, Lujain Younes Al-Arman, Dana Banihani, Aya Mustafa, Noor Abualdahab, Giuseppe Broggi, Gabriele Gaggero, Nataniele Piol, Pietro Fiaschi, Evelina Miele, Felice Giangaspero","doi":"10.5414/NP301415","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly.</p><p><strong>Materials and methods: </strong>We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization.</p><p><strong>Results: </strong>DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma.</p><p><strong>Conclusion: </strong>This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"41 1","pages":"12-17"},"PeriodicalIF":0.8000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool.\",\"authors\":\"Hiba Alzoubi, Francesca Gianno, Yussuf Abuelhaija, Angam Ayyoub Najadat, Ahmad Mustafa, Aws Younes Al-Arman, Lujain Younes Al-Arman, Dana Banihani, Aya Mustafa, Noor Abualdahab, Giuseppe Broggi, Gabriele Gaggero, Nataniele Piol, Pietro Fiaschi, Evelina Miele, Felice Giangaspero\",\"doi\":\"10.5414/NP301415\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly.</p><p><strong>Materials and methods: </strong>We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization.</p><p><strong>Results: </strong>DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma.</p><p><strong>Conclusion: </strong>This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.</p>\",\"PeriodicalId\":55251,\"journal\":{\"name\":\"Clinical Neuropathology\",\"volume\":\"41 1\",\"pages\":\"12-17\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neuropathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5414/NP301415\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neuropathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5414/NP301415","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool.
Aim: Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly.
Materials and methods: We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization.
Results: DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma.
Conclusion: This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.
期刊介绍：
Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
