SARS - CoV-2在动物中的自然传播和实验模型

IF 18 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2021-10-01 Epub Date: 2021-10-26 DOI:10.30802/AALAS-CM-21-000046

Jessica C Gomes Noll, Gabriela M do Nascimento, Diego G Diel

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引用次数: 0

摘要

自2020年3月世界卫生组织宣布新冠肺炎为大流行以来，数百万人感染了SARS-CoV-2并死于感染。一些家养和野生物种也感染了这种疾病。从一开始，科学家们就一直致力于开发疫苗和建立能够预防疾病发展并改善感染者临床结果的疗法。为了了解病毒发病机制和感染动力学的各个方面，并支持疫苗和治疗方法的临床前评估，已经对多种动物物种进行了评估，以用作人类疾病和感染的模型。在这里，我们讨论了家养和圈养野生动物的自然严重急性呼吸系统综合征冠状病毒2型感染，以及几个物种对实验性感染该病毒的易感性。

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Natural Transmission and Experimental Models of SARS CoV-2 Infection in Animals.

Since the World Health Organization declared COVID-19 a pandemic in March 2020, millions of people have contracted SARS-CoV-2 and died from the infection. Several domestic and wild species have contracted the disease as well. From the beginning, scientists have been working to develop vaccines and establish therapies that can prevent disease development and improve the clinical outcome in infected people. To understand various aspects of viral pathogenesis and infection dynamics and to support preclinical evaluation of vaccines and therapeutics, a diverse number of animal species have been evaluated for use as models of the disease and infection in humans. Here, we discuss natural SARS-CoV-2 infection of domestic and captive wild animals, as well as the susceptibility of several species to experimental infection with this virus.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.