肿瘤微环境:结直肠癌上皮-间质转化的不可忽视的驱动因素。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2021-11-11 DOI:10.1017/erm.2021.13
Lei Han, Shuyi Wang, Chen Wei, Yan Fang, Sihao Huang, Tailang Yin, Bin Xiong, Chaogang Yang
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引用次数: 16

摘要

癌症仍然是世界范围内死亡的主要原因,转移仍然是癌症患者治疗失败的主要原因。上皮-间质转化(Epithelial-mesenchymal transition, EMT)已被证明在上皮源性癌的转移级联中起关键作用。肿瘤微环境(tumor microenvironment, TME)是指肿瘤细胞产生和生存的局部组织环境,不仅包括肿瘤细胞本身,还包括肿瘤细胞周围的成纤维细胞、免疫和炎症细胞、胶质细胞等细胞,以及细胞间基质、微血管和来自附近区域的浸润生物分子等,已被证明广泛参与了肿瘤的发生和发展。越来越多的研究表明,一方面,TME中的间充质细胞可以与肿瘤细胞建立“串扰”,以调节其EMT程序;另一方面,emt肿瘤细胞可以通过培养基质细胞为自身的生长创造有利的环境。近期,课课组对TME中肿瘤相关巨噬细胞(tumor associated macrophages, tam)与结直肠癌(colorectal cancer, CRC)细胞的相互作用进行了一系列研究,证实tam与CRC细胞在细胞因子或外泌体介导下的相互作用可通过调节肿瘤细胞的EMT过程和tam的m2型极化过程,共同促进CRC的转移。本文综述了EMT在癌症中的研究现状,总结了TME在EMT中的重要作用,并对TME在结直肠癌中诱发EMT的机制进行了最新研究,旨在为认识和抵抗肿瘤转移提供新的思路。
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Tumour microenvironment: a non-negligible driver for epithelial-mesenchymal transition in colorectal cancer.

Cancer remains the leading cause of death worldwide, and metastasis is still the major cause of treatment failure for cancer patients. Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in the metastasis cascade of epithelium-derived carcinoma. Tumour microenvironment (TME) refers to the local tissue environment in which tumour cells produce and live, including not only tumour cells themselves, but also fibroblasts, immune and inflammatory cells, glial cells and other cells around them, as well as intercellular stroma, micro vessels and infiltrated biomolecules from the nearby areas, which has been proved to widely participate in the occurrence and progress of cancer. Emerging and accumulating studies indicate that, on one hand, mesenchymal cells in TME can establish 'crosstalk' with tumour cells to regulate their EMT programme; on the other, EMT-tumour cells can create a favourable environment for their own growth via educating stromal cells. Recently, our group has conducted a series of studies on the interaction between tumour-associated macrophages (TAMs) and colorectal cancer (CRC) cells in TME, confirming that the interaction between TAMs and CRC cells mediated by cytokines or exosomes can jointly promote the metastasis of CRC by regulating the EMT process of tumour cells and the M2-type polarisation process of TAMs. Herein, we present an overview to describe the current knowledge about EMT in cancer, summarise the important role of TME in EMT, and provide an update on the mechanisms of TME-induced EMT in CRC, aiming to provide new ideas for understanding and resisting tumour metastasis.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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