高性能 P 手性膦配体的合成与应用。

IF 4.4 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI:10.2183/pjab.97.026
Tsuneo Imamoto
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引用次数: 0

摘要

金属催化不对称合成是经济、环保地生产有用光学活性化合物的最重要方法之一。不对称转化的成功与否在很大程度上取决于与中心金属配位的手性配体的结构和电子特性,因此开发高效配体,尤其是手性膦配体,一直是该领域的重要研究课题。这篇综述文章介绍了在磷原子上具有手性中心的 P 手性膦配体的合成和应用。本文以膦硼烷为中间体,合成了合理设计的 P 手性膦配体。在各种过渡金属催化的不对称反应中,构象刚性强且电子丰富的 P 手性膦配体表现出优异的对映选择性和高催化活性。此外,还介绍了铑催化不对称氢化的最新机理研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Synthesis and applications of high-performance P-chiral phosphine ligands.

Metal-catalyzed asymmetric synthesis is one of the most important methods for the economical and environmentally benign production of useful optically active compounds. The success of the asymmetric transformations is significantly dependent on the structure and electronic properties of the chiral ligands coordinating to the center metals, and hence the development of highly efficient ligands, especially chiral phosphine ligands, has long been an important research subject in this field. This review article describes the synthesis and applications of P-chiral phosphine ligands possessing chiral centers at the phosphorus atoms. Rationally designed P-chiral phosphine ligands are synthesized by the use of phosphine-boranes as the intermediates. Conformationally rigid and electron-rich P-chiral phosphine ligands exhibit excellent enantioselectivity and high catalytic activity in various transition-metal-catalyzed asymmetric reactions. Recent mechanistic studies of rhodium-catalyzed asymmetric hydrogenation are also described.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: The Proceedings of the Japan Academy Ser. B (PJA-B) is a scientific publication of the Japan Academy with a 90-year history, and covers all branches of natural sciences, except for mathematics, which is covered by the PJA-A. It is published ten times a year and is distributed widely throughout the world and can be read and obtained free of charge through the world wide web.
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