合成代谢类固醇所致胆汁酸性肾病1例报告及文献复习。

Clinical Nephrology. Case Studies Pub Date : 2021-11-09 eCollection Date: 2021-01-01 DOI:10.5414/CNCS110711
Hamdan Al Awadhi, Sarah Al Qassimi, Aya Akhras, Leal Herlitz, Muriel Ghosn
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引用次数: 2

摘要

胆汁酸肾病也被称为胆汁淤积性肾病,是一种罕见且被忽视的急性肾损伤形式,发生在严重高胆红素血症的背景下。确切的病因尚不清楚,并且缺乏针对这种临床状况的治疗指南。已知合成代谢类固醇有时会引起肝毒性,导致急性肾损伤。我们报告一个27岁的男性患者谁发展为胆汁酸肾病的严重高胆红素血症继发于合成代谢类固醇引起的肝损伤的结果。他管理得很保守。我们回顾了目前有关胆汁酸肾病的病因、病理生理学、诊断和治疗的文献,试图阐明这一临床疾病,这可能是诊断和治疗的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Bile acid nephropathy induced by anabolic steroids: A case report and review of the literature.

Bile acid nephropathy also known as cholemic nephropathy is a rare and overlooked form of acute kidney injury that occurs in the setting of severe hyperbilirubinemia. The exact etiology remains unknown, and there is a lack of treatment guidelines for this clinical condition. Anabolic steroids are known to cause hepatoxicity occasionally leading to acute kidney injury. We report the case of a 27-year-old male patient who developed bile acid nephropathy as a result of severe hyperbilirubinemia secondary to anabolic steroids-induced liver injury. He was conservatively managed. We review the current literature touching on the etiology, pathophysiology, diagnosis, and management of bile acid nephropathy in an attempt to shed light on this clinical condition, which may present as a diagnostic and therapeutic challenge.

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