Huijin Hu, Tao Chen, Wenbin Liu, Yiping Shen, Qiushuang Li, Yuhong Zhou, Baodong Ye, Dijiong Wu
{"title":"异基因造血干细胞移植重症再生障碍性贫血患者阴阳瘀证辨证及其与铁代谢、cAMP/cGMP、17-OH-CS、甲状腺素的相关性","authors":"Huijin Hu, Tao Chen, Wenbin Liu, Yiping Shen, Qiushuang Li, Yuhong Zhou, Baodong Ye, Dijiong Wu","doi":"10.2147/JBM.S332171","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To better understanding and differentiation of traditional Chinese medicine (TCM) syndromes in severe aplastic anemia (SAA) patients undergoing hematopoietic stem cell transplantation (Allo-HSCT) and their correlation with iron metabolism, cAMP/cGMP, 17-OH-CS and thyroxine.</p><p><strong>Methods: </strong>Eighteen patients with SAA who underwent HSCT were enrolled. The syndrome was evaluated before conditioning and days after stem cell reinfusion (-10d, -1d, +7d, +30d, +60d, and +90d). The correlation of TCM syndrome (Yin, Yang, and stasis) to cyclic nucleotides, 17-OH-CS, thyroxine, and iron metabolism were analyzed and compared to data from normal subjects.</p><p><strong>Results: </strong>More \"Yin deficiency\" (n=11, 11/18) syndrome was observed before HSCT, and nearly 61% was complicated with \"blood stasis\". After conditioning, the proportion of \"kidney Yin and Yang deficiency\" increased to 61.6%. Fourteen days after HSCT, the syndrome developed into \"Spleen-Kidney Yang Deficiency,\" and the stasis score decreased. On +90day, majority patients were diagnosed with \"Kidney Yang Deficiency\" (35.7%) or \"Spleen-Kidney Yang Deficiency\" (28.6%), and 88.9% were diagnosed without stasis. The correlation analysis showed that cGMP might represent \"Deficient Yang\" as well as low total triiodothyronine (T3) and free T3 (FT3). There was also a positive relation between labile plasma iron (LPI), hepcidin, soluble transferrin receptor (sTfR), and \"Yin deficiency\", and the last two factors, along with marrow nitric oxide synthase were also positively related to \"Stasis\" syndrome.</p><p><strong>Conclusion: </strong>During HSCT, the syndrome evolved from \"kidney Yin and Yang deficiency\" to \"kidney Yang deficiency\" or \"spleen-kidney Yang deficiency\", and the \"stasis\" along with \"Yin deficiency\" syndromes were quickly relieved within 90 days. The changes of cyclic nucleotides, 17-OH-CS, thyroxine, and iron metabolism indexes can be applied for better differentiation of TCM syndrome.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/df/jbm-12-975.PMC8598128.pdf","citationCount":"2","resultStr":"{\"title\":\"Differentiation of Yin, Yang and Stasis Syndromes in Severe Aplastic Anemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation and Their Correlation with Iron Metabolism, cAMP/cGMP, 17-OH-CS and Thyroxine.\",\"authors\":\"Huijin Hu, Tao Chen, Wenbin Liu, Yiping Shen, Qiushuang Li, Yuhong Zhou, Baodong Ye, Dijiong Wu\",\"doi\":\"10.2147/JBM.S332171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To better understanding and differentiation of traditional Chinese medicine (TCM) syndromes in severe aplastic anemia (SAA) patients undergoing hematopoietic stem cell transplantation (Allo-HSCT) and their correlation with iron metabolism, cAMP/cGMP, 17-OH-CS and thyroxine.</p><p><strong>Methods: </strong>Eighteen patients with SAA who underwent HSCT were enrolled. The syndrome was evaluated before conditioning and days after stem cell reinfusion (-10d, -1d, +7d, +30d, +60d, and +90d). The correlation of TCM syndrome (Yin, Yang, and stasis) to cyclic nucleotides, 17-OH-CS, thyroxine, and iron metabolism were analyzed and compared to data from normal subjects.</p><p><strong>Results: </strong>More \\\"Yin deficiency\\\" (n=11, 11/18) syndrome was observed before HSCT, and nearly 61% was complicated with \\\"blood stasis\\\". After conditioning, the proportion of \\\"kidney Yin and Yang deficiency\\\" increased to 61.6%. Fourteen days after HSCT, the syndrome developed into \\\"Spleen-Kidney Yang Deficiency,\\\" and the stasis score decreased. On +90day, majority patients were diagnosed with \\\"Kidney Yang Deficiency\\\" (35.7%) or \\\"Spleen-Kidney Yang Deficiency\\\" (28.6%), and 88.9% were diagnosed without stasis. The correlation analysis showed that cGMP might represent \\\"Deficient Yang\\\" as well as low total triiodothyronine (T3) and free T3 (FT3). There was also a positive relation between labile plasma iron (LPI), hepcidin, soluble transferrin receptor (sTfR), and \\\"Yin deficiency\\\", and the last two factors, along with marrow nitric oxide synthase were also positively related to \\\"Stasis\\\" syndrome.</p><p><strong>Conclusion: </strong>During HSCT, the syndrome evolved from \\\"kidney Yin and Yang deficiency\\\" to \\\"kidney Yang deficiency\\\" or \\\"spleen-kidney Yang deficiency\\\", and the \\\"stasis\\\" along with \\\"Yin deficiency\\\" syndromes were quickly relieved within 90 days. The changes of cyclic nucleotides, 17-OH-CS, thyroxine, and iron metabolism indexes can be applied for better differentiation of TCM syndrome.</p>\",\"PeriodicalId\":15166,\"journal\":{\"name\":\"Journal of Blood Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2021-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/df/jbm-12-975.PMC8598128.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Blood Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/JBM.S332171\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Blood Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/JBM.S332171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Differentiation of Yin, Yang and Stasis Syndromes in Severe Aplastic Anemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation and Their Correlation with Iron Metabolism, cAMP/cGMP, 17-OH-CS and Thyroxine.
Objective: To better understanding and differentiation of traditional Chinese medicine (TCM) syndromes in severe aplastic anemia (SAA) patients undergoing hematopoietic stem cell transplantation (Allo-HSCT) and their correlation with iron metabolism, cAMP/cGMP, 17-OH-CS and thyroxine.
Methods: Eighteen patients with SAA who underwent HSCT were enrolled. The syndrome was evaluated before conditioning and days after stem cell reinfusion (-10d, -1d, +7d, +30d, +60d, and +90d). The correlation of TCM syndrome (Yin, Yang, and stasis) to cyclic nucleotides, 17-OH-CS, thyroxine, and iron metabolism were analyzed and compared to data from normal subjects.
Results: More "Yin deficiency" (n=11, 11/18) syndrome was observed before HSCT, and nearly 61% was complicated with "blood stasis". After conditioning, the proportion of "kidney Yin and Yang deficiency" increased to 61.6%. Fourteen days after HSCT, the syndrome developed into "Spleen-Kidney Yang Deficiency," and the stasis score decreased. On +90day, majority patients were diagnosed with "Kidney Yang Deficiency" (35.7%) or "Spleen-Kidney Yang Deficiency" (28.6%), and 88.9% were diagnosed without stasis. The correlation analysis showed that cGMP might represent "Deficient Yang" as well as low total triiodothyronine (T3) and free T3 (FT3). There was also a positive relation between labile plasma iron (LPI), hepcidin, soluble transferrin receptor (sTfR), and "Yin deficiency", and the last two factors, along with marrow nitric oxide synthase were also positively related to "Stasis" syndrome.
Conclusion: During HSCT, the syndrome evolved from "kidney Yin and Yang deficiency" to "kidney Yang deficiency" or "spleen-kidney Yang deficiency", and the "stasis" along with "Yin deficiency" syndromes were quickly relieved within 90 days. The changes of cyclic nucleotides, 17-OH-CS, thyroxine, and iron metabolism indexes can be applied for better differentiation of TCM syndrome.
期刊介绍:
The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine (blood components, stem cell transplantation, apheresis, gene based therapeutics), Blood collection, Donor issues, Transmittable diseases, and Blood banking logistics, Immunohematology, Artificial and alternative blood based therapeutics, Hematology including disorders/pathology related to leukocytes/immunology, red cells, platelets and hemostasis, Biotechnology/nanotechnology of blood related medicine, Legal aspects of blood medicine, Historical perspectives. Original research, short reports, reviews, case reports and commentaries are invited.