SARS-CoV-2疫苗相关的亚急性甲状腺炎

IF 3.9 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Endocrinological Investigation Pub Date : 2022-07-01 Epub Date: 2022-02-19 DOI:10.1007/s40618-022-01767-w
G Yorulmaz, M Sahin Tekin
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引用次数: 15

摘要

目的:随着2019冠状病毒病(COVID-19)的出现,亚急性甲状腺炎(SAT)病例在全球范围内呈上升趋势。COVID-19疫苗相关的SAT病例也有报道。在这篇文章中,我们介绍了11例与疫苗相关的SAT病例的数据。方法:11例患者纳入研究。评估患者接种的疫苗类型、疫苗接种后发生SAT的时间、症状和实验室结果、给予的治疗以及对治疗的反应。结果:患者年龄26 ~ 73岁。其中男性4例,女性7例。6例患者在BNT162b2辉瑞/BioNTech COVID-19 mRNA疫苗®后出现症状,其中4例患者在Coronavac灭活SARS-CoV-2疫苗®后出现症状。在一名患者中,首次给药BNT162b2后出现SAT,在两次给药Coronavac后出现SAT。接种疫苗后至出现症状的平均时间为22天(15-37)。结论:含有整个病毒的疫苗和含有遗传物质的疫苗都能引起SAT,这一事实表明,触发因素可能是病毒蛋白,而不是整个病毒颗粒。虽然在已发表的疫苗相关的SAT病例中,糖皮质激素通常是首选的,但我们更倾向于在我们的患者中使用非甾体抗炎治疗,以获得足够的疫苗抗体反应。考虑到正在进行的大流行,没有足够的信息表明患有SAT的患者是否可以安全地重新接种疫苗。对这些患者的治疗和再接种需要进一步的研究得出结论。
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SARS-CoV-2 vaccine-associated subacute thyroiditis.

Purpose: With coronavirus disease 2019 (COVID-19), subacute thyroiditis (SAT) cases are on the rise all over the world. COVID-19 vaccine-associated SAT cases have also been reported. In this article, we present our data on 11 vaccine-associated SAT cases.

Methods: Eleven patients were included in the study. Type of the vaccines patients received, time to the occurrence of SAT after vaccination, symptoms and laboratory findings, treatment given, and response to treatment were evaluated.

Results: The age of patients ranged from 26 to 73. Four of the patients were males, and seven were females. Symptoms of six patients were seen after BNT162b2 Pfizer/BioNTech COVID-19 mRNA vaccine®, and four of them after Coronavac inactivated SARS-CoV-2 vaccine®. In one patient, SAT developed after the first dose of BNT162b2, administered after two doses of Coronavac. The average time to the onset of symptoms was 22 days (15-37) after vaccination.

Conclusions: The fact that both whole virus containing and genetic material containing vaccines cause SAT suggests that the trigger may be viral proteins rather than the whole viral particle. Although corticosteroids are commonly preferred in published vaccine-associated SAT cases, we preferred nonsteroidal anti-inflammatory therapy in our patients for sufficient vaccine antibody response. There is not enough information about whether patients who develop SAT can be revaccinated safely considering the ongoing pandemic. Further research is needed for a conclusion in the treatment and revaccination of these patients.

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来源期刊
Journal of Endocrinological Investigation
Journal of Endocrinological Investigation 医学-内分泌学与代谢
CiteScore
8.70
自引率
7.40%
发文量
242
审稿时长
3 months
期刊介绍: The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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