血清尿酸作为维持性血液透析患者心脑血管疾病的预测因子。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-06-14 Print Date: 2022-06-01 DOI:10.2478/rjim-2021-0039
Najmeh Khodabandeh, Elahe Taziki, Toktam Alirezaei
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引用次数: 0

摘要

背景:在普通人群中,高尿酸血症与心脑血管疾病(CVD)的风险增加有关。然而,在血液透析(HD)患者中,低血清尿酸(SUA)增加了死亡的风险。考虑到心血管疾病是维持性HD患者的主要死亡原因,本研究旨在确定SUA对该人群心血管疾病结局的预测价值。方法:在这项为期两年的随访前瞻性研究中,从2017年3月至2020年,纳入205例维持性HD门诊患者。记录患者的人口统计数据、基础疾病、血清测试结果以及心血管疾病事件和死亡率的两年随访结果。结果:共有130例(63%)患者符合分析条件;男性占62.9%;参与者平均年龄59±13岁。随访时,冠状动脉疾病43.2%,外周动脉疾病26.5%,脑血管疾病20.5%;52.3%的患者需要血管造影,4.5%的患者死于心血管疾病。52例患者SUA≤5.4 mg/dL, 19例患者5.5-6.1 mg/dL, 59例患者SUA≥6.2 mg/dL,在平均年龄、性别分布、脑血管疾病发生及心血管病死率等方面存在显著差异(结论:低SUA可预测HD患者2年脑血管疾病的发病率)。然而,SUA水平对两年冠状动脉事件、外周动脉疾病和心血管死亡率没有显著的预测作用。
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Serum uric acid as a predictor of cardio- and cerebro-vascular diseases in maintenance hemodialysis patients.

Background: Hyperuricemia is associated with an increased risk of cardio-and cerebrovascular disease (CVD) in general population. However, in the hemodialysis (HD) patients, low serum uric acid (SUA) increases the risk of mortality. Considering that CVD is the principal cause of death among maintenance HD patients, the present study aimed to determine the predictive value of SUA for CVD outcome in this population.Methods: In this two-year follow-up prospective study, 205 outpatients under maintenance HD were enrolled from March 2017 to 2020. Patients' demographic data, underlying diseases, and the results of serum tests, as well as two-year follow-up results of CVD events and mortality were recorded.Results: A total of 130 (63%) patients were eligible for analysis; 62.9% were male; mean age of participants was 59±13years. At follow-up, coronary artery disease was observed in 43.2%, peripheral artery disease in 26.5%, and cerebrovascular disease in 20.5%; angiography was required in 52.3% and 4.5% died of CVD. SUA was ≤5.4 mg/dL in 52 patients, 5.5-6.1 mg/dL in 19, and ≥6.2 mg/dL in 59 patients with significant difference based on mean age, sex distribution, occurrence of cerebrovascular disease and cardiovascular mortality (P<0.05). Patients with cerebrovascular disease had a significantly lower SUA levels (P=0.006). Logistic regression showed the significant effect of SUA on the occurrence of cerebrovascular disease (P=0.008).Conclusion: Low SUA can predict two-year incidence of cerebrovascular disease in HD patients. However, SUA levels did not show significant predictive effect on two-year coronary events, peripheral artery disease and cardiovascular mortality.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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