我们能否将血清 SCUBE 1 水平作为阻塞性睡眠呼吸暂停低通气综合征的生物标记物？

IF 2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2024-09-01 Epub Date: 2021-11-27 DOI:10.1080/08869634.2021.2005917

Omer Tarik Selcuk, Gamze Ozturk Yılmaz, Hamit Yasar Ellidag, Oğuzhan Ilden, Nursel Turkoglu Selcuk, Gokhan Yilmaz, Nuray Ensari, Hande Konsuk Unlu, Hülya Eyigor

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引用次数: 0

摘要

目的研究SCUBE1水平，这是一种血管生物学生物标志物，可确定OSA治疗期间心血管事件的预后：研究共纳入了 129 名患者。方法：共纳入 129 名患者，其中 30 人被诊断为单纯性打鼾，99 人被诊断为 OSA：在男性患者中，SCUBE1 非 REM AHI、低通气指数、总呼吸暂停指数、平均 SO2、最小 SO2 和 < 90% 饱和度持续时间之间存在明显相关性：与其他OSA水平相比，男性重度OSA患者的血清SCUBE1水平升高更多，并且发现高血清SCUBE1水平与OSA患者的低氧水平相关。SCUBE1 生物标志物可与男性严重 OSA 相关。男性患者的 SCUBE1 评分在 OSA 组间存在显著统计学差异（p = 0.002），而女性患者的 SCUBE1 评分则没有显著统计学差异（p = 0.498）。今后的 SCUBE1 研究必须对男性和女性进行评估。

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Can we use serum SCUBE 1 levels as a biomarker in obstructive sleep apnea hypopnea syndrome?

Objective: To examine the SCUBE1 level, a biomarker in vascular biology that could determine the prognosis of cardiovascular events during OSA treatment.

Methods: In total, 129 patients were included in the study. Thirty were diagnosed with simple snoring and 99 with OSA.

Results: In males, significant correlation was determined between SCUBE1 non-REM AHI, hypopnea index, total apnea index, mean SO₂, minimum SO₂, and < 90% saturation duration.

Conclusion: Serum SCUBE1 levels increased more in male patients with severe OSA compared to other OSA levels, and high serum SCUBE1 levels were found to be associated with lower oxygen levels in OSA patients. The SCUBE1 biomarker can correlate with severe OSA in males. There was a statistically significant difference between OSA groups in terms of SCUBE1 score for male patients (p = 0.002) but not for females (p = 0.498). It is important that future SCUBE1 studies evaluate males vs. females.

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.