Manisha B Patil, T Lavanya, C Meena Kumari, Shishir Ram Shetty, Khalid Gufran, Vipin Viswanath, C Swarnalatha, J Suresh Babu, Abhishek Singh Nayyar
{"title":"血清铜蓝蛋白作为口腔癌前期和癌的标志物。","authors":"Manisha B Patil, T Lavanya, C Meena Kumari, Shishir Ram Shetty, Khalid Gufran, Vipin Viswanath, C Swarnalatha, J Suresh Babu, Abhishek Singh Nayyar","doi":"10.4103/jcar.jcar_10_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aim: </strong>Oxidative stress leads to a compensatory increase in levels of serum ceruloplasmin in patients with such imbalances. Greater than normal serum ceruloplasmin levels are noticed in numerous cancers including the leukemias and Hodgkin's lymphoma. The purpose of the present study was to estimate and evaluate the efficacy of serum ceruloplasmin levels as a potential biomarker in the early detection of oral potentially malignant epithelial lesions (PMELs) including leukoplakia, oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC) patients.</p><p><strong>Materials and methods: </strong>The present observational study was conducted over a period of 2 years wherein 100 subjects aged between 18 to 60 years were divided into four groups with Group A consisting of 25 healthy controls, Group B and C with 25 patients each, clinically diagnosed with oral leukoplakia and OSMF and Group D with 25 patients clinically diagnosed and histopathologically proven OSCC. The patients were subjected to incisional biopsy after routine hematological investigation while the same sera samples were used for analysis of serum ceruloplasmin levels.</p><p><strong>Statistical analysis used: </strong>Comparison of serum ceruloplasmin levels between the groups was performed using one way analysis of variance (one way ANOVA) test while <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean serum ceruloplasmin levels were found to be 43.19 ± 1.90mg/dl in subjects of group A, 47.68 ± 1.51mg/dl in group B, 47.74 ± 1.45mg/dl in group C and 47.73 ± 0.74mg/dl in group D. Using one-way ANOVA, statistically significant variations were found in the values of mean serum ceruloplasmin levels in subjects of the four groups (F-value = 59.58, <i>P</i> = 0.0001).</p><p><strong>Conclusions: </strong>The observations of the present study revealed that serum ceruloplasmin levels were found to be raised in all 3 study groups including oral leukoplakia, OSMF and OSCC as compared to the controls while the results were found to be statistically significant.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"15"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531576/pdf/","citationCount":"7","resultStr":"{\"title\":\"Serum ceruloplasmin as cancer marker in oral pre-cancers and cancers.\",\"authors\":\"Manisha B Patil, T Lavanya, C Meena Kumari, Shishir Ram Shetty, Khalid Gufran, Vipin Viswanath, C Swarnalatha, J Suresh Babu, Abhishek Singh Nayyar\",\"doi\":\"10.4103/jcar.jcar_10_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aim: </strong>Oxidative stress leads to a compensatory increase in levels of serum ceruloplasmin in patients with such imbalances. Greater than normal serum ceruloplasmin levels are noticed in numerous cancers including the leukemias and Hodgkin's lymphoma. The purpose of the present study was to estimate and evaluate the efficacy of serum ceruloplasmin levels as a potential biomarker in the early detection of oral potentially malignant epithelial lesions (PMELs) including leukoplakia, oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC) patients.</p><p><strong>Materials and methods: </strong>The present observational study was conducted over a period of 2 years wherein 100 subjects aged between 18 to 60 years were divided into four groups with Group A consisting of 25 healthy controls, Group B and C with 25 patients each, clinically diagnosed with oral leukoplakia and OSMF and Group D with 25 patients clinically diagnosed and histopathologically proven OSCC. The patients were subjected to incisional biopsy after routine hematological investigation while the same sera samples were used for analysis of serum ceruloplasmin levels.</p><p><strong>Statistical analysis used: </strong>Comparison of serum ceruloplasmin levels between the groups was performed using one way analysis of variance (one way ANOVA) test while <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean serum ceruloplasmin levels were found to be 43.19 ± 1.90mg/dl in subjects of group A, 47.68 ± 1.51mg/dl in group B, 47.74 ± 1.45mg/dl in group C and 47.73 ± 0.74mg/dl in group D. Using one-way ANOVA, statistically significant variations were found in the values of mean serum ceruloplasmin levels in subjects of the four groups (F-value = 59.58, <i>P</i> = 0.0001).</p><p><strong>Conclusions: </strong>The observations of the present study revealed that serum ceruloplasmin levels were found to be raised in all 3 study groups including oral leukoplakia, OSMF and OSCC as compared to the controls while the results were found to be statistically significant.</p>\",\"PeriodicalId\":52464,\"journal\":{\"name\":\"Journal of Carcinogenesis\",\"volume\":\"20 \",\"pages\":\"15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531576/pdf/\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Carcinogenesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jcar.jcar_10_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Environmental Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Carcinogenesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jcar.jcar_10_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Environmental Science","Score":null,"Total":0}
引用次数: 7
摘要
背景和目的:氧化应激导致这种失衡的患者血清铜蓝蛋白水平代偿性增加。在包括白血病和霍奇金淋巴瘤在内的许多癌症中，血清铜蓝蛋白水平均高于正常水平。本研究的目的是评估血清铜蓝蛋白水平作为早期检测口腔潜在恶性上皮病变(pmel)的潜在生物标志物的有效性，包括白斑、口腔黏膜下纤维化(OSMF)和口腔鳞状细胞癌(OSCC)患者。材料与方法:本观察性研究为期2年，将100名年龄在18 - 60岁的受试者分为4组，a组25名健康对照，B组和C组各25名临床诊断为口腔白斑和OSMF的患者，D组25名临床诊断并经组织病理学证实为OSCC的患者。患者在常规血液学检查后行切口活检，同时用相同的血清样本分析血清铜蓝蛋白水平。统计学方法:组间血清铜蓝蛋白水平比较采用单因素方差分析(one way ANOVA)检验，以P < 0.05为差异有统计学意义。结果:A组、B组、C组、d组血清蓝蛋白平均水平分别为43.19±1.90mg/dl、47.68±1.51mg/dl、47.74±1.45mg/dl、47.73±0.74mg/dl。采用单因素方差分析，四组患者血清蓝蛋白平均水平差异有统计学意义(f值= 59.58,P = 0.0001)。结论:本研究观察发现，与对照组相比，包括口腔白斑、OSMF和OSCC在内的3个研究组血清铜蓝蛋白水平均升高，且结果具有统计学意义。
Serum ceruloplasmin as cancer marker in oral pre-cancers and cancers.
Background and aim: Oxidative stress leads to a compensatory increase in levels of serum ceruloplasmin in patients with such imbalances. Greater than normal serum ceruloplasmin levels are noticed in numerous cancers including the leukemias and Hodgkin's lymphoma. The purpose of the present study was to estimate and evaluate the efficacy of serum ceruloplasmin levels as a potential biomarker in the early detection of oral potentially malignant epithelial lesions (PMELs) including leukoplakia, oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC) patients.
Materials and methods: The present observational study was conducted over a period of 2 years wherein 100 subjects aged between 18 to 60 years were divided into four groups with Group A consisting of 25 healthy controls, Group B and C with 25 patients each, clinically diagnosed with oral leukoplakia and OSMF and Group D with 25 patients clinically diagnosed and histopathologically proven OSCC. The patients were subjected to incisional biopsy after routine hematological investigation while the same sera samples were used for analysis of serum ceruloplasmin levels.
Statistical analysis used: Comparison of serum ceruloplasmin levels between the groups was performed using one way analysis of variance (one way ANOVA) test while P < 0.05 was considered statistically significant.
Results: The mean serum ceruloplasmin levels were found to be 43.19 ± 1.90mg/dl in subjects of group A, 47.68 ± 1.51mg/dl in group B, 47.74 ± 1.45mg/dl in group C and 47.73 ± 0.74mg/dl in group D. Using one-way ANOVA, statistically significant variations were found in the values of mean serum ceruloplasmin levels in subjects of the four groups (F-value = 59.58, P = 0.0001).
Conclusions: The observations of the present study revealed that serum ceruloplasmin levels were found to be raised in all 3 study groups including oral leukoplakia, OSMF and OSCC as compared to the controls while the results were found to be statistically significant.
期刊介绍：
Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. Primary areas of interest to the journal include: physical and chemical carcinogenesis and mutagenesis; processes influencing or modulating carcinogenesis, such as DNA repair; genetics, nutrition, and metabolism of carcinogens; the mechanism of action of carcinogens and modulating agents; epidemiological studies; and, the formation, detection, identification, and quantification of environmental carcinogens. Manuscripts that contribute to the understanding of cancer prevention are especially encouraged for submission
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
