Francesk Mulita, Georgios-Ioannis Verras, Fotios Iliopoulos, Charalampos Kaplanis, Elias Liolis, Levan Tchabashvili, Christos Tsilivigkos, Ioannis Perdikaris, Argyro Sgourou, Adamantia Papachatzopoulou, Ioannis Maroulis
{"title":"对乙酰氨基酚单药治疗与对乙酰氨基酚/帕雷可昔布联合治疗与哌替啶/对乙酰氨基酚联合治疗在甲状腺切除术患者中的镇痛效果。","authors":"Francesk Mulita, Georgios-Ioannis Verras, Fotios Iliopoulos, Charalampos Kaplanis, Elias Liolis, Levan Tchabashvili, Christos Tsilivigkos, Ioannis Perdikaris, Argyro Sgourou, Adamantia Papachatzopoulou, Ioannis Maroulis","doi":"10.5114/pm.2021.110955","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to investigate the analgesic effect of 3 different regimens of combination analgesics administered to patients undergoing thyroidectomy.</p><p><strong>Material and methods: </strong>A total of 152 patients undergoing total or subtotal thyroidectomy were enrolled. Patients allocated to group A received a combination of intravenous (IV) paracetamol and intramuscular (IM) pethidine, patients in group B received a combination of IV paracetamol and IV parecoxib, while patients in group C received IV paracetamol monotherapy.</p><p><strong>Results: </strong>The analgesic regimens of groups A and B were found to be of equivalent efficacy (<i>p</i>-value = 1.000). In contrast, patients in group C (paracetamol monotherapy) had higher numerical rating scale scores, compared to both patients in groups A (<i>p</i>-value < 0.001) and B (<i>p</i>-value < 0.001).</p><p><strong>Conclusions: </strong>The combinations of IV paracetamol with either IM pethidine or IV parecoxib are superior to IV paracetamol monotherapy in achieving pain control in patients undergoing thyroid surgery.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"20 4","pages":"226-230"},"PeriodicalIF":2.5000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/82/MR-20-45662.PMC8764955.pdf","citationCount":"3","resultStr":"{\"title\":\"Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy.\",\"authors\":\"Francesk Mulita, Georgios-Ioannis Verras, Fotios Iliopoulos, Charalampos Kaplanis, Elias Liolis, Levan Tchabashvili, Christos Tsilivigkos, Ioannis Perdikaris, Argyro Sgourou, Adamantia Papachatzopoulou, Ioannis Maroulis\",\"doi\":\"10.5114/pm.2021.110955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The purpose of this study was to investigate the analgesic effect of 3 different regimens of combination analgesics administered to patients undergoing thyroidectomy.</p><p><strong>Material and methods: </strong>A total of 152 patients undergoing total or subtotal thyroidectomy were enrolled. Patients allocated to group A received a combination of intravenous (IV) paracetamol and intramuscular (IM) pethidine, patients in group B received a combination of IV paracetamol and IV parecoxib, while patients in group C received IV paracetamol monotherapy.</p><p><strong>Results: </strong>The analgesic regimens of groups A and B were found to be of equivalent efficacy (<i>p</i>-value = 1.000). In contrast, patients in group C (paracetamol monotherapy) had higher numerical rating scale scores, compared to both patients in groups A (<i>p</i>-value < 0.001) and B (<i>p</i>-value < 0.001).</p><p><strong>Conclusions: </strong>The combinations of IV paracetamol with either IM pethidine or IV parecoxib are superior to IV paracetamol monotherapy in achieving pain control in patients undergoing thyroid surgery.</p>\",\"PeriodicalId\":55643,\"journal\":{\"name\":\"Przeglad Menopauzalny\",\"volume\":\"20 4\",\"pages\":\"226-230\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/82/MR-20-45662.PMC8764955.pdf\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Przeglad Menopauzalny\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/pm.2021.110955\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/11/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad Menopauzalny","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/pm.2021.110955","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/11/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy.
Introduction: The purpose of this study was to investigate the analgesic effect of 3 different regimens of combination analgesics administered to patients undergoing thyroidectomy.
Material and methods: A total of 152 patients undergoing total or subtotal thyroidectomy were enrolled. Patients allocated to group A received a combination of intravenous (IV) paracetamol and intramuscular (IM) pethidine, patients in group B received a combination of IV paracetamol and IV parecoxib, while patients in group C received IV paracetamol monotherapy.
Results: The analgesic regimens of groups A and B were found to be of equivalent efficacy (p-value = 1.000). In contrast, patients in group C (paracetamol monotherapy) had higher numerical rating scale scores, compared to both patients in groups A (p-value < 0.001) and B (p-value < 0.001).
Conclusions: The combinations of IV paracetamol with either IM pethidine or IV parecoxib are superior to IV paracetamol monotherapy in achieving pain control in patients undergoing thyroid surgery.
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