掌握非常规的分泌机制，以桥梁细胞应激信号到细胞外蛋白质组。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2021-10-15 eCollection Date: 2021-11-01 DOI:10.15698/cst2021.11.259

Constantinos Demetriades, Julian Nüchel, Markus Plomann

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引用次数: 0

摘要

细胞对压力的适应是生存、代谢、生理和疾病的一个重要的内稳态过程。细胞通过改变信号通路的活性来响应应激刺激(如营养缺乏、生长因子剥夺、缺氧、低能量等)，并通过定性和定量地改变细胞内、表面和细胞外蛋白质组与环境相互作用。这种微妙的交流是如何发生的是细胞生物学研究中的一个热门话题，对人类疾病具有重要意义。

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GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome.

Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity of signaling pathways, and interact with their environment by qualitatively and quantitatively modifying their intracellular, surface, and extracellular proteomes. How this delicate communication takes place is a hot topic in cell biological research, and has important implications for human disease.

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.