YAP/TAZ转录调控机制。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2021-10-29 eCollection Date: 2021-11-01 DOI:10.15698/cst2021.11.258
Giusy Battilana, Francesca Zanconato, Stefano Piccolo
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引用次数: 18

摘要

基因表达失调是细胞转化、肿瘤发生和转移的内在因素。癌症特异性基因表达谱源于由遗传和表观遗传缺陷以及肿瘤微环境异常信号推动的基因调控网络。这些致癌信号最终通过转录因子(TFs)、共激活因子和染色质调节因子的募集,参与一系列效应基因的顺式调控元件的转录机制。也就是说,癌细胞中的基因表达究竟是无数调控的混乱产物,还是由少数tf(主调控因子)精心策划的相对有序的过程,一直是个谜。最近对YAP/TAZ共激活子的研究有助于在这一突出问题上取得新的突破,揭示了肿瘤细胞通过一小组相互关联的tf及其核伙伴的参与,劫持了在发育和再生过程中活跃的生长程序。
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Mechanisms of YAP/TAZ transcriptional control.

Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor microenvironment. These oncogenic signals ultimately engage the transcriptional machinery on the cis -regulatory elements of a host of effector genes, through recruitment of transcription factors (TFs), co-activators and chromatin regulators. That said, whether gene-expression in cancer cells is the chaotic product of myriad regulations or rather a relatively ordered process orchestrated by few TFs (master regulators) has long remained enigmatic. Recent work on the YAP/TAZ co-activators has been instrumental to break new ground into this outstanding issue, revealing that tumor cells hijack growth programs that are active during development and regeneration through engagement of a small set of interconnected TFs and their nuclear partners.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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