Raed M Tayyem, Haitham G Qandeel, Hamzeh I Al-Balas, Farah R Tayyem, Jehad Z Fataftah, Mahmoud I Al-Balas
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The mean weight loss was greater in the EPGB group than in the EIBT group (15.6 kg vs. 9.3 kg, P < 0.001). However, the percentage excess weight loss and the satiety score were greater in the EIBT group (59.1% vs. 42.2%, P < 0.001; and 3.5 vs. 2.3, P < 0.001) respectively. The procedure duration was shorter for EIBT patients (10 min vs. 15 min, P < 0.001). The postoperative complication rate recorded in the EPGB group was significantly higher (30% vs. 9%, P = 0.001). Adverse symptoms lasted longer in EPGB (5.2 days vs. 0.7 days, P < 0.001). Both groups enjoyed similar improvements in QoL.</p><p><strong>Conclusion: </strong>EIBT is a safe and effective treatment for mild obesity. Although the weight loss was greater in the EPGB group, the percentage excess weight loss, procedure duration, postoperative complications, and symptom duration were significantly better in the EIBT group. 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引用次数: 6
摘要
背景:进行了一项前瞻性病例匹配研究，比较内镜下胃内肉毒毒素A (EIBT)与内镜下计划胃球囊(EPGB)治疗肥胖的安全性和有效性。方法:176例患者(年龄和性别匹配)平均分为EIBT组(n = 88)和EPGB组(n = 88)。接受EIBT的患者体重指数(BMI)限制在25至35 kg/m2之间，而EPGB组允许BMI >25 kg/m2。主要测量结果为体重减轻、手术时间、并发症、早期饱腹感和生活质量(QoL)。结果:患者平均随访6个月。EPGB组的平均体重减轻量大于EIBT组(15.6 kg对9.3 kg, P < 0.001)。然而，EIBT组的超重减重百分比和饱腹感评分更高(59.1% vs 42.2%， P < 0.001;3.5 vs. 2.3, P < 0.001)。EIBT患者的手术时间较短(10分钟vs 15分钟，P < 0.001)。EPGB组术后并发症发生率明显高于对照组(30% vs. 9%， P = 0.001)。EPGB组不良症状持续时间更长(5.2天比0.7天，P < 0.001)。两组在生活质量方面都有类似的改善。结论:EIBT是一种安全有效的治疗轻度肥胖的方法。虽然EPGB组的体重减轻更大，但EIBT组的体重减轻百分比、手术时间、术后并发症和症状持续时间明显更好。两组患者的生活质量改善具有可比性。
Comparison of safety and efficacy of intragastric botulinum toxin-A versus gastric balloon.
Background: A prospective case-matched study was conducted to compare the safety and efficacy of endoscopic intragastric botulinum toxin-A (EIBT) versus endoscopically planned gastric balloon (EPGB), as a treatment for obesity.
Methods: A total of 176 patients (matched for age and sex) were equally divided to undergo EIBT (n = 88) or EPGB (n = 88). Patients who received EIBT were restricted to a body mass index (BMI) of 25 to 35 kg/m2, whereas a BMI >25 kg/m2 was allowed in the EPGB group. The main measured outcomes were weight loss, procedure duration, complications, early satiety, and quality of life (QoL).
Results: The patients were followed up for a mean of 6 months. The mean weight loss was greater in the EPGB group than in the EIBT group (15.6 kg vs. 9.3 kg, P < 0.001). However, the percentage excess weight loss and the satiety score were greater in the EIBT group (59.1% vs. 42.2%, P < 0.001; and 3.5 vs. 2.3, P < 0.001) respectively. The procedure duration was shorter for EIBT patients (10 min vs. 15 min, P < 0.001). The postoperative complication rate recorded in the EPGB group was significantly higher (30% vs. 9%, P = 0.001). Adverse symptoms lasted longer in EPGB (5.2 days vs. 0.7 days, P < 0.001). Both groups enjoyed similar improvements in QoL.
Conclusion: EIBT is a safe and effective treatment for mild obesity. Although the weight loss was greater in the EPGB group, the percentage excess weight loss, procedure duration, postoperative complications, and symptom duration were significantly better in the EIBT group. QoL improvement was comparable between the two groups.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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