Renata O Pereira, Luana A Correia, Daniela Farah, Geovana Komoni, Vera Farah, Patricia Fiorino
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引用次数: 0
摘要
高脂肪对人体肾脏损害的影响尚未完全阐明。动物实验对于了解人类疾病的发病机制至关重要。本系统性综述旨在收集有关高脂饮食在 Wistar 大鼠肾脏脂肪毒性和纤维化发展过程中的作用的证据,以了解高脂饮食是否是研究高脂诱发肾损伤的理想模型。我们在 PUBMED、EMBASE、Lilacs 和 Web of Science 数据库中进行了系统检索,检索时间从开始到 2021 年 5 月。使用SYRCLE收费系统对偏倚风险进行了评估。两名审稿人独立筛选摘要并审阅全文。共纳入了 11 项研究。根据动物的年龄和性别、方案的时间以及饮食中的脂肪量,造成的损害各不相同。总之,Wistar 大鼠是评估高脂饮食对肾脏影响的适当动物模型。亮点高脂饮食可能会促进 Wistar 大鼠的肾脏损伤。
Wistar rat as an animal model to study high-fat induced kidney damage: a systematic review.
The effects of high-fat-associated kidney damage in humans are not completely elucidated. Animal experiments are essential to understanding the mechanisms underlying human diseases. This systematic review aimed to compile evidence of the role of a high-fat diet during the development of renal lipotoxicity and fibrosis of Wistar rats to understand whether this is a satisfactory model for the study of high fat-induced kidney damage. We conducted systematic searches in PUBMED, EMBASE, Lilacs, and Web of Science databases from inception until May 2021. The risk of bias was assessed using SYRCLE toll. Two reviewers independently screened abstracts and reviewed full-text articles. A total of 11 studies were included. The damage varied depending on the age and sex of the animals, time of protocol, and amount of fat in the diet. In conclusion, the Wistar rat is an adequate animal model to assess the effects of a high-fat diet on the kidneys.HighlightsA high-fat diet may promote kidney damage in Wistar rats.Wistar rat is efficient as an animal model to study high-fat-induced kidney damage.The effect of the diet depends on the fat amount, consumption time, and animal age.
期刊介绍:
Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders.
The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications.
Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics:
-Dysregulation of hormone receptors and signal transduction
-Contribution of gene variants and gene regulatory processes
-Impairment of intermediary metabolism at the cellular level
-Secretion and metabolism of peptides and other factors that mediate cellular crosstalk
-Therapeutic strategies for managing metabolic diseases
Special issues dedicated to topics in the field will be published regularly.