COVID-19 的免疫学和免疫疗法。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2021-12-17 DOI:10.1017/erm.2021.30
Yixin Liu, Xinsheng Zhou, Xuan Liu, Xiaotao Jiang
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引用次数: 0

摘要

由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)引起的冠状病毒病 2019(COVID-19)正在全球大流行,对世界经济和日常生活产生了重大影响。COVID-19 的症状从无症状到发热、呼吸困难、急性呼吸窘迫和多器官衰竭。危重病例通常发生在老年人和原有疾病患者身上。通过与血管紧张素转换酶 2 受体结合,SARS-CoV-2 可进入宿主细胞并在其中复制,发挥细胞毒性作用,引起局部和全身炎症。目前,COVID-19 尚无特效治疗方法,而免疫疗法在增强宿主对病毒的免疫力和减轻压倒性炎症方面发挥着至关重要的作用,因此一直备受关注。在这篇综述中,我们总结了 COVID-19 的免疫致病特征,并重点介绍了免疫疗法的最新进展,从而为开发新的潜在疗法提供思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The immunology and immunotherapy for COVID-19.

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and significantly impacts the world economy and daily life. Symptoms of COVID-19 range from asymptomatic to fever, dyspnoea, acute respiratory distress and multiple organ failure. Critical cases often occur in the elderly and patients with pre-existing conditions. By binding to the angiotensin-converting enzyme 2 receptor, SARS-CoV-2 can enter and replicate in the host cell, exerting a cytotoxic effect and causing local and systemic inflammation. Currently, there is no specific treatment for COVID-19, and immunotherapy has consistently attracted attention because of its essential role in boosting host immunity to the virus and reducing overwhelming inflammation. In this review, we summarise the immunopathogenic features of COVID-19 and highlight recent advances in immunotherapy to illuminate ideas for the development of new potential therapies.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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