探索有氧运动和正念训练对老年痴呆症高危人群认知功能的影响：可行性概念验证研究

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY American Journal of Alzheimers Disease and Other Dementias Pub Date : 2021-01-01 DOI:10.1177/15333175211039094

Elena Salmoirago-Blotcher, Dyuti Trivedi, Shira Dunsiger, Kristie Harris, Christopher Breault, Cláudia Yang Santos, Kristen Walaska, Peter Snyder, Ronald Cohen

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引用次数: 0

摘要

研究目的：本研究旨在探讨有氧训练（AT）、正念训练（MT）或两者（MT + AT）的可行性、可接受性以及对老年痴呆症高危人群认知功能的初步影响：方法：参与者随机接受有氧训练、正念训练、两者或常规护理（UC）。在基线、治疗结束（EOT）和基线后 6 个月时计算非痴呆成人的注意力、语言流畅性和外显记忆（ZAVEN）的 Z 值：在 36 名参加者（12 名男性，24 名女性，平均年龄 70.1 岁）中，97% 的人在 6 个月后仍留在研究中。在EOT时，MT的ZAVEN评分高于UC（b = .43，P =.03）和AT（b = .26，P = .10），而MT + AT则无差异。在 6 个月的随访中也观察到类似的模式（所有 P 值 = .10）：讨论：MT 可改善有痴呆风险的老年人的认知功能。这些初步研究结果还需要在完全有效的 RCT 中得到证实。

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Exploring Effects of Aerobic Exercise and Mindfulness Training on Cognitive Function in Older Adults at Risk of Dementia: A Feasibility, Proof-of-Concept Study.

Objectives: This study sought to explore feasibility, acceptability, and preliminary effects of aerobic training (AT), mindfulness training (MT), or both (MT + AT) on cognitive function in older individuals at risk of dementia.

Method: Participants were randomized to AT, MT, both, or usual care (UC). Z-scores of attention, verbal fluency, and episodic memory for non-demented adults (ZAVEN) were computed at baseline, end of treatment (EOT), and 6 months since baseline.

Results: Of the 36 enrolled participants (12 M, 24 F, mean age = 70.1 years), 97% were retained in the study at 6 months. At EOT, MT had higher ZAVEN scores than UC (b = .43, P =.03) and AT (b = .26, P = .10), while no differences were seen with MT + AT. A similar pattern was observed at a 6 month follow-up (all P values = .10).

Discussion: MT may improve cognitive function in older individuals at risk of dementia. These preliminary findings need to be confirmed in a fully powered RCT.

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).