芬兰心血管疾病危险因素人群中的APOE基因型、脂质谱和相关临床标志物

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2022-01-01 Epub Date: 2021-12-23 DOI:10.1159/000520864
Heidi Leskinen, Maaria Tringham, Heli Karjalainen, Terhi Iso-Touru, Hanna-Leena Hietaranta-Luoma, Pertti Marnila, Juha-Matti Pihlava, Timo Hurme, Hannu Puolijoki, Kari Åkerman, Sari Mäkinen, Mari Sandell, Kirsi Vähäkangas, Raija Tahvonen, Susanna Rokka, Anu Hopia
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引用次数: 1

摘要

APOE ε4等位基因易导致高胆固醇,并增加患阿尔茨海默病和心血管疾病(cvd)等生活方式相关疾病的风险。本研究的目的是分析APOE基因型与脂质代谢和生活方式因素之间的相互关系,其中心血管疾病危险因素在中年芬兰人中很常见。方法:对211名参与者进行APOE ε基因型、生理参数和健康及饮食相关血浆标志物的分析。生活方式的选择由一份问卷决定。结果:APOE基因型ε3/ε4和ε4/ε4 (ε4组)占34.1%。基因型ε3/ε3 (ε3组)频率为54.5%。ε2载体(ε2基团);ε2/ε2、ε2/ε3和ε2/ε4)占11.4%;基因型为ε2/ε4的占1.9%。ε2携带者LDL和总胆固醇水平低于ε3和ε4组(p < 0.05),而ε3和ε4组差异无统计学意义。与ε4组相比,ε2携带者血浆饱和脂肪酸(sfa)含量较高(p < 0.01), ω -6脂肪酸含量较低(p = 0.01)。与未携带ε2等位基因的个体相比,携带ε2的个体22:4n-6和22:5n-6的比例较高(p < 0.05),携带ε2等位基因的个体24:5n-3和24:6n-3的比例较低(p < 0.05)。结论:ε2组血浆脂肪酸谱表现为SFA较高,omega-6脂肪酸比例较低。与ε4组相比,他们较低的胆固醇值表明患心血管疾病的风险较低。新发现ε2携带者的22:4n-6、22:5n-6、24:5n-3和24:6n-3的比例与不携带ε2等位基因的个体不同。脂肪酸组成差异的意义还有待研究。
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APOE Genotypes, Lipid Profiles, and Associated Clinical Markers in a Finnish Population with Cardiovascular Disease Risk Factors.

Introduction: The APOE ε4 allele predisposes to high cholesterol and increases the risk for lifestyle-related diseases such as Alzheimer's disease and cardiovascular diseases (CVDs). The aim of this study was to analyse interrelationships of APOE genotypes with lipid metabolism and lifestyle factors in middle-aged Finns among whom the CVD risk factors are common.

Methods: Participants (n = 211) were analysed for APOE ε genotypes, physiological parameters, and health- and diet-related plasma markers. Lifestyle choices were determined by a questionnaire.

Results: APOE genotypes ε3/ε4 and ε4/ε4 (ε4 group) represented 34.1% of the participants. Genotype ε3/ε3 (ε3 group) frequency was 54.5%. Carriers of ε2 (ε2 group; ε2/ε2, ε2/ε3 and ε2/ε4) represented 11.4%; 1.9% were of the genotype ε2/ε4. LDL and total cholesterol levels were lower (p < 0.05) in the ε2 carriers than in the ε3 or ε4 groups, while the ε3 and ε4 groups did not differ. Proportions of plasma saturated fatty acids (SFAs) were higher (p < 0.01), and omega-6 fatty acids lower (p = 0.01) in the ε2 carriers compared with the ε4 group. The ε2 carriers had a higher (p < 0.05) percentage of 22:4n-6 and 22:5n-6 and a lower (p < 0.05) percentage of 24:5n-3 and 24:6n-3 than individuals without the ε2 allele.

Conclusions: The plasma fatty-acid profiles in the ε2 group were characterized by higher SFA and lower omega-6 fatty-acid proportions. Their lower cholesterol values indicated a lower risk for CVD compared with the ε4 group. A novel finding was that the ε2 carriers had different proportions of 22:4n-6, 22:5n-6, 24:5n-3, and 24:6n-3 than individuals without the ε2 allele. The significance of the differences in fatty-acid composition remains to be studied.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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