肠道微生物群在胃肠道癌症中的作用

IF 2.9 4区医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-02-03 DOI:10.1007/s00005-021-00641-6

Marta Grochowska, Karol Perlejewski, Tomasz Laskus, Marek Radkowski

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引用次数: 6

摘要

胃肠道(GI)微生物群紊乱可能在胃肠道癌症的发展中发挥重要作用，但其潜在机制仍不清楚。虽然有些细菌似乎有助于致癌，但其他细菌似乎具有保护作用。到目前为止，只有一种细菌(幽门螺杆菌)被国际癌症研究机构列为人类致癌物，但其他许多细菌正在进行深入研究。大多数关于微生物群在胃肠道肿瘤发生中的作用的研究集中在胰腺癌和结直肠癌上，其中以下三种细菌:幽门螺杆菌、大肠杆菌和牙龈卟啉单胞菌是可能的致病因素。本文就细菌在胃肠道肿瘤发生中的作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Gut Microbiota in Gastrointestinal Tract Cancers

Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species: Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis as likely causative factors. This review summarizes the role of bacteria in GI tract oncogenesis.

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来源期刊

Archivum Immunologiae et Therapiae Experimentalis 医学-免疫学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.