重症与非重症COVID-19患者免疫参数的动态差异

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Discovery medicine Pub Date : 2021-03-01

Qiang Li, Wei Xu, Weixia Li, Chenlu Huang, Ling Fei, Xudong Xie, Liang Chen

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引用次数: 0

摘要

目的:比较重症与非重症COVID-19患者免疫学指标的动态差异。方法:对664例新冠肺炎患者(重症31例，非重症633例)的细胞因子谱和淋巴细胞亚群进行纵向分析。结果:重症患者年龄高于非重症患者(64岁vs 40岁，p0.05)。入院后35 d，重症患者淋巴细胞、CD3+ T细胞、CD4+ T细胞、CD8+ T细胞、CD45+ T细胞绝对计数均明显低于非重症患者(p0.05)。入院后第1 ~ 3天T淋巴细胞亚群下降达到高峰，非重症组逐渐升高，重症组入院后第4 ~ 35天维持在较低水平。结论:细胞因子谱和T淋巴细胞亚群的动态变化与COVID-19严重程度相关。

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Dynamic Differences of Immunological Parameters Between Severe and Non-severe COVID-19 Patients.

Objective: We aimed to compare the dynamic differences of immunological parameters between severe and non-severe COVID-19 patients.

Methods: The cytokine profiles and lymphocyte subsets of 664 patients with COVID-19 (31 severe cases and 633 non-severe cases) were longitudinally analyzed.

Results: Compared with non-severe cases, severe cases had a higher age (64 vs. 40 years, p<0.001), more common comorbidity (74.2% vs. 20.5%, p<0.001), and lymphopenia (0.7 vs. 1.4x109/L, p<0.001). Severe cases had markedly higher levels of IL-6, IL-8, and IL-10 from baseline to 35 days after admission than non-severe cases (p<0.001). No significant differences were observed in the dynamic levels of IL-1beta, IL-2, IL-4, IL-5, IL-12, IL-17, TNF-alpha, IFN-alpha, and IFN-gamma between severe and non-severe COVID-19 patients (p>0.05). The absolute counts of lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, and CD45+ T cells were markedly lower in severe patients with COVID-19 compared with those in non-severe patients from baseline to 35 days after admission (p<0.001). No significant differences were observed in the dynamic levels of white cells count, CD19+ B cells count, and NK cells count between severe and non-severe COVID-19 patients (p>0.05). The decrease of T lymphocyte subsets reached its peak at day 1 to 3 after admission, and they gradually increased in the non-severe group, but sustained at low levels in the severe group at day 4 to 35 after admission.

Conclusion: The dynamic changes of cytokine profiles and T lymphocyte subsets are related with the severity of COVID-19.

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来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.