{"title":"一种新型三维异金属配位聚合物：发光性能及在急性脑梗死中的护理应用价值。","authors":"Li Cong, Yun-Zhi Pan, Ying-Hui Qin, Ji-Na Jiang","doi":"10.1080/15685551.2022.2033431","DOIUrl":null,"url":null,"abstract":"<p><p>With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {[Cd<sub>2</sub>Ca<sub>2</sub>(L)<sub>2</sub>(DMF)<sub>2</sub>(H<sub>2</sub>O)<sub>7</sub>]·(DMF)·2(H<sub>2</sub>O)}<sub>n</sub> (<b>1</b>, H<sub>4</sub>L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N'-Dimethylformamide). Furthermore, the solids of <b>1</b> shows ligand-centered luminescence at room temperature. It not only evaluated the treatment and nursing application value on acute cerebral infarction, but also explored the related mechanism. Above of all, ELISA assay measured the content of the MMP-9 released into the cerebrospinal fluid, and the real time RT-PCR was implemented and the NF-κB activation in the brain tissue was measured.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820831/pdf/","citationCount":"0","resultStr":"{\"title\":\"A new 3D heterometallic coordination polymer: luminescent property and nursing application value on acute cerebral infarction.\",\"authors\":\"Li Cong, Yun-Zhi Pan, Ying-Hui Qin, Ji-Na Jiang\",\"doi\":\"10.1080/15685551.2022.2033431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {[Cd<sub>2</sub>Ca<sub>2</sub>(L)<sub>2</sub>(DMF)<sub>2</sub>(H<sub>2</sub>O)<sub>7</sub>]·(DMF)·2(H<sub>2</sub>O)}<sub>n</sub> (<b>1</b>, H<sub>4</sub>L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N'-Dimethylformamide). Furthermore, the solids of <b>1</b> shows ligand-centered luminescence at room temperature. It not only evaluated the treatment and nursing application value on acute cerebral infarction, but also explored the related mechanism. Above of all, ELISA assay measured the content of the MMP-9 released into the cerebrospinal fluid, and the real time RT-PCR was implemented and the NF-κB activation in the brain tissue was measured.</p>\",\"PeriodicalId\":11170,\"journal\":{\"name\":\"Designed Monomers and Polymers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2022-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820831/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Designed Monomers and Polymers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/15685551.2022.2033431\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Designed Monomers and Polymers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/15685551.2022.2033431","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
通过柔性四羧酸配体与Cd(II)和Ca(II)离子的溶剂热反应，得到了一种新的异金属配位聚合物，分子式为{[Cd2Ca2(L)2(DMF)2(H2O)7]·(DMF)·2(H2O)}n (1, H4L为5-(双(4-羧基苄基)氨基)间苯二甲酸，DMF为n, n '-二甲基甲酰胺)。此外，1的固体在室温下表现出配体中心发光。评价急性脑梗死的治疗和护理应用价值，并探讨其相关机制。首先，ELISA法测定释放到脑脊液中的MMP-9的含量，实时RT-PCR法测定脑组织中NF-κB的活化情况。
A new 3D heterometallic coordination polymer: luminescent property and nursing application value on acute cerebral infarction.
With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {[Cd2Ca2(L)2(DMF)2(H2O)7]·(DMF)·2(H2O)}n (1, H4L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N'-Dimethylformamide). Furthermore, the solids of 1 shows ligand-centered luminescence at room temperature. It not only evaluated the treatment and nursing application value on acute cerebral infarction, but also explored the related mechanism. Above of all, ELISA assay measured the content of the MMP-9 released into the cerebrospinal fluid, and the real time RT-PCR was implemented and the NF-κB activation in the brain tissue was measured.
期刊介绍：
Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work.
The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications.
DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to:
-macromolecular science, initiators, macroinitiators for macromolecular design
-kinetics, mechanism and modelling aspects of polymerization
-new methods of synthesis of known monomers
-new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization)
-functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers
-new polymeric materials with biomedical applications
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