{"title":"一种新型三维异金属配位聚合物：发光性能及在急性脑梗死中的护理应用价值。","authors":"Li Cong, Yun-Zhi Pan, Ying-Hui Qin, Ji-Na Jiang","doi":"10.1080/15685551.2022.2033431","DOIUrl":null,"url":null,"abstract":"<p><p>With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {[Cd<sub>2</sub>Ca<sub>2</sub>(L)<sub>2</sub>(DMF)<sub>2</sub>(H<sub>2</sub>O)<sub>7</sub>]·(DMF)·2(H<sub>2</sub>O)}<sub>n</sub> (<b>1</b>, H<sub>4</sub>L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N'-Dimethylformamide). Furthermore, the solids of <b>1</b> shows ligand-centered luminescence at room temperature. It not only evaluated the treatment and nursing application value on acute cerebral infarction, but also explored the related mechanism. Above of all, ELISA assay measured the content of the MMP-9 released into the cerebrospinal fluid, and the real time RT-PCR was implemented and the NF-κB activation in the brain tissue was measured.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"12-18"},"PeriodicalIF":16.4000,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820831/pdf/","citationCount":"0","resultStr":"{\"title\":\"A new 3D heterometallic coordination polymer: luminescent property and nursing application value on acute cerebral infarction.\",\"authors\":\"Li Cong, Yun-Zhi Pan, Ying-Hui Qin, Ji-Na Jiang\",\"doi\":\"10.1080/15685551.2022.2033431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {[Cd<sub>2</sub>Ca<sub>2</sub>(L)<sub>2</sub>(DMF)<sub>2</sub>(H<sub>2</sub>O)<sub>7</sub>]·(DMF)·2(H<sub>2</sub>O)}<sub>n</sub> (<b>1</b>, H<sub>4</sub>L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N'-Dimethylformamide). Furthermore, the solids of <b>1</b> shows ligand-centered luminescence at room temperature. It not only evaluated the treatment and nursing application value on acute cerebral infarction, but also explored the related mechanism. Above of all, ELISA assay measured the content of the MMP-9 released into the cerebrospinal fluid, and the real time RT-PCR was implemented and the NF-κB activation in the brain tissue was measured.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":\" \",\"pages\":\"12-18\"},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2022-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820831/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/15685551.2022.2033431\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/15685551.2022.2033431","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
通过柔性四羧酸配体与Cd(II)和Ca(II)离子的溶剂热反应，得到了一种新的异金属配位聚合物，分子式为{[Cd2Ca2(L)2(DMF)2(H2O)7]·(DMF)·2(H2O)}n (1, H4L为5-(双(4-羧基苄基)氨基)间苯二甲酸，DMF为n, n '-二甲基甲酰胺)。此外，1的固体在室温下表现出配体中心发光。评价急性脑梗死的治疗和护理应用价值，并探讨其相关机制。首先，ELISA法测定释放到脑脊液中的MMP-9的含量，实时RT-PCR法测定脑组织中NF-κB的活化情况。
A new 3D heterometallic coordination polymer: luminescent property and nursing application value on acute cerebral infarction.
With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {[Cd2Ca2(L)2(DMF)2(H2O)7]·(DMF)·2(H2O)}n (1, H4L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N'-Dimethylformamide). Furthermore, the solids of 1 shows ligand-centered luminescence at room temperature. It not only evaluated the treatment and nursing application value on acute cerebral infarction, but also explored the related mechanism. Above of all, ELISA assay measured the content of the MMP-9 released into the cerebrospinal fluid, and the real time RT-PCR was implemented and the NF-κB activation in the brain tissue was measured.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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