G-CSF治疗对肾移植后白细胞减少和急性排斥反应的影响。

IF 0.3 Q4 TRANSPLANTATION International Journal of Organ Transplantation Medicine Pub Date : 2021-01-01
J Schneider, M Henningsen, P Pisarski, G Walz, B Jänigen
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引用次数: 0

摘要

背景:白细胞减少是肾移植后常见的问题。治疗方法通常包括减少免疫抑制治疗,这与排斥和同种异体移植物丢失的风险增加有关。粒细胞集落刺激因子(G-CSF)被用作提高白细胞计数的治疗选择;然而,对急性排斥反应的影响是有争议的。目的:本研究的目的是检查G-CSF治疗后急性排斥反应的发生率。方法:我们回顾性评估2007年1月至2017年12月在本中心接受肾移植和GCSF治疗后白细胞减少的患者,并在配对对分析中与白细胞计数最小匹配的对照组进行比较。结果:我们确定了12例患者,他们接受了g - csf治疗,累积剂量为10.74µg/kg体重,时间为4.3天。结论:G-CSF治疗可减少肾移植后白细胞减少的持续时间,但也可能增加急性排斥反应的风险。
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Impact of G-CSF Therapy on Leukopenia and Acute Rejection Following Kidney Transplantation.

Background: Leukopenia is a common problem after kidney transplantation. The therapeutic approach typically includes a reduction of the immunosuppressive therapy, which is associated with an increased risk of rejection and allograft loss. Granulocyte colony-stimulating factor (G-CSF) is used as a therapeutic option to raise the leukocyte blood count; however, the effect on acute rejections is controversial.

Objective: The goal of this study is to examine the incidence of acute rejections following G-CSF therapy.

Methods: We retrospectively evaluated patients with leukopenia following kidney transplantation and GCSF therapy between January 2007 and December 2017 at our center compared to controls with matched minimal leucocyte blood count in a matched pair analysis.

Results: We identified 12 patients, who received G-CSF therapy with a cumulative dose of 10.74 µg/kg body weight over a time frame of 4.3 days. G-CSF therapy resulted in a significantly shorter time period with leucocytes <3,000/µL (9.5 vs. 16.6 days), but also trended towards an increased risk of rejection within the next 30 days with three patients in the G-CSF group and no patient in the control group (p=0.06) developing an acute biopsy-proven rejection. Infection and mortality rate in the subsequent year were not different between groups.

Conclusion: G-CSF therapy decreases the duration of leukopenia post-kidney transplantation, but may also increase the risk of an acute rejection.

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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.
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