光化性角化病病变的总数不能通过可见病变的数量来预测:现场定向治疗的后果

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current Therapeutic Research-clinical and Experimental Pub Date : 2022-01-01 DOI:10.1016/j.curtheres.2021.100661

Eggert Stockfleth MD PhD , Nathalie Bégeault MSc , Alain Delarue MD

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引用次数: 2

摘要

光化性角化病是发生在被阳光广泛损伤的皮肤区域的角化病变。利用先前发表的一项III期随机对照临床试验的数据，研究了至少5例光化性角化病患者在任何治疗前可见的光化性角化病病变数量与5-氟尿嘧啶乳膏显示的癌变病灶总数之间的潜在联系。我们的分析表明，可见光化性角化病的基线数量不能很好地反映癌变领域的实际病变数量，因此有必要向患者解释癌变领域的概念。(中国临床医学杂志，2022;82: XXX-XXX)©2022 Elsevier HS Journals, Inc。

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The Overall Number of Actinic Keratosis Lesions Is Not Predictable by the Number of Visible Lesions: Consequences for Field-Directed Therapies

Actinic keratoses are keratotic lesions occurring on skin areas extensively damaged by sunlight. Using data from a previously published Phase III randomized, controlled clinical trial in patients with at least 5 actinic keratoses, we explored the potential link between the number of visible actinic keratosis lesions before any treatment and the total number of lesions of the field cancerization as revealed by 5-fluorouracil cream. Our analysis suggests that the baseline number of visible actinic keratoses is a poor indicator of the real number of lesions in the field of cancerization, reinforcing the need to explain the field cancerization concept to patients. (Curr Ther Res Clin Exp. 2022; 82:XXX–XXX) © 2022 Elsevier HS Journals, Inc.

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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