银屑病患者的非酒精性脂肪性肝病(NAFLD):系统性治疗对肝脏的影响

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2021-12-07 eCollection Date: 2021-01-01 DOI:10.2147/PTT.S342911
Deepak M W Balak, Stefano Piaserico, Ismail Kasujee
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引用次数: 10

摘要

人们对牛皮癣与非酒精性脂肪性肝病(NAFLD)之间的关系越来越感兴趣,NAFLD是一种普遍的肝脏疾病,其特征是过度脂肪储存和炎症,可进展为纤维化和癌症。牛皮癣患者发展为NAFLD的风险高两倍,发展为更严重的肝脏疾病的风险高两倍。牛皮癣和NAFLD有共同的危险因素,如吸烟、饮酒、代谢综合征及其组成紊乱。此外,牛皮癣和NAFLD都依赖于全身性低度炎症,这可能导致NAFLD进行性肝损伤的恶性循环,以及潜在牛皮癣的恶化。其他重要的共同病理生理途径包括外周胰岛素抵抗和氧化应激。NAFLD作为银屑病的重要合并症应引起临床重视。本文综述了银屑病与NAFLD之间的流行病学和病理生理关系,讨论了银屑病患者NAFLD的临床意义,并总结了银屑病全身治疗的肝毒性和肝保护潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Non-Alcoholic Fatty Liver Disease (NAFLD) in Patients with Psoriasis: A Review of the Hepatic Effects of Systemic Therapies.

There is increasing interest in the association between psoriasis and non-alcoholic fatty liver disease (NAFLD), which is a prevalent liver disease characterized by excessive fat storage and inflammation that can progress to fibrosis and cancer. Patients with psoriasis have a two-fold higher risk to develop NAFLD and a higher risk to progress to more severe liver disease. Psoriasis and NAFLD share common risk factors such as smoking, alcohol consumption, and the presence of metabolic syndrome and its component disorders. In addition, both psoriasis and NAFLD hinge upon a systemic low-grade inflammation that can lead to a vicious cycle of progressive liver damage in NAFLD as well as worsening of the underlying psoriasis. Other important shared pathophysiological pathways include peripheral insulin resistance and oxidative stress. NAFLD should receive clinical awareness as important comorbidity in psoriasis. In this review, we assess the recent literature on the epidemiological and pathophysiological relationship of psoriasis and NAFLD, discuss the clinical implications of NAFLD in psoriasis patients, and summarize the hepatotoxic and hepatoprotective potential of systemic psoriasis therapies.

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