Undefined Oncological Risk of Fat Grafting Procedures in the Breast.

soft atrophy, pigmentation, local tissue Chronic radiation-induced injury functional impairment at reversing these changes by use of radioprotective agents, tissue debridement, skin grafting, local and free vascularized flaps, recently, adipose tissue grafting (2). The concept of fat grafting in 1893 plastic its in the breast, extremities, orbit, head neck. the undefined risk of oncological recurrence resulting from fat grafting into the irradiated breast tissue (1). The relationship between fat grafts and breast cancer cells explored in the past. One of the most extensive patient series was published by Petit et al. (3) in consisting of a multicenter analysis of 513 patients undergoing fat grafting after breast cancer. With an average follow-up time of 19.2 months, the study revealed a local recurrence rate of 2.4% (1.5%/year) and an overall recurrence of 5.6% (3.6%/ year). A higher locoregional recurrence rate was observed in carcinoma in situ patients compared to those with invasive cancer. with cancer in situ) between 1988 - 2009, with a three-year minimum follow-up period. Five patients (3.6% of the overall population) were diagnosed with local recurrence post fat grafting compared to four patients (2.9% of the overall population) between surgery and the first fat grafting procedure. It was concluded that fat grafting after mastectomy did not increase local oncological recurrence. Basic science and clinical studies have provided contradictory data on these procedures’ safety profiles, making it difficult to make a definitive claim about their oncologic safety. The primary concerns are the lack of an ideal control group for comparison, retrospective analysis by most publications, and inadequate follow-up. The lack of standardization of fat harvesting, processing, and technique further adds to the challenge. As proposed by Kenny et al (1), better animal models and a larger working group with a longer follow-up period can provide these answers. Additionally, we strongly feel that high-quality research focusing on irradiated tissue’s oncological potential following fat grafting can provide a better clinical correlation. We propose that basic science models be based on samples from the same patient as opposed to laboratory-stored cell lines. This can be done for individual case reports for better homology. Guidelines with a longer definite follow-up period and a strong control group must be accomplished. A definite wait time from previous procedures (if any), based on individual risk factors, must be implemented for any clinical trial in the field. The need for prospectively controlled long-term clinical trials must be encouraged. These measures will help answer these questions sooner and enable healthcare providers to safely use the fat grafting technique.