免疫蛋白酶体在黑色素瘤和结肠癌中肿瘤-免疫细胞相互作用中的作用

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-01-22 DOI:10.1007/s00005-022-00644-x
Hanna Leister, Felix F. Krause, Rouzbeh Mahdavi, Ulrich Steinhoff, Alexander Visekruna
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引用次数: 2

摘要

蛋白酶体参与参与参与肿瘤生长的重要细胞和代谢过程,使这种蛋白酶复合体成为癌症治疗的有吸引力的靶点。与普遍可用的组成型蛋白酶体相比,免疫蛋白酶体的酶活性增加与肿瘤浸润免疫细胞有关,如抗原呈递细胞和T淋巴细胞。在各种肿瘤中,通过蛋白酶体产生肿瘤相关抗原来提供有效的抗肿瘤免疫,这对T淋巴细胞根除癌症至关重要。关于免疫蛋白酶体在肿瘤细胞和浸润性免疫细胞之间通讯中的作用的知识是有限的。新的数据表明,免疫蛋白酶体在肿瘤发生中的参与比以前认为的更复杂。在肠道中,来自共生细菌和食物的不同信号可能导致慢性炎症和炎症驱动的癌症的发作,免疫蛋白酶体通过调节促炎因子的表达发挥致瘤特性。相反,在黑色素瘤和非小细胞肺癌癌症中,免疫蛋白酶体通过促进有效的抗肿瘤免疫来对抗癌症的发展。在这篇综述中,我们强调了免疫蛋白酶体有助于炎症信号传导和肿瘤发展,或支持抗癌免疫的潜力。此外,我们还讨论了与调节肿瘤微环境中免疫蛋白酶体活性相关的癌症治疗的新治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Role of Immunoproteasomes in Tumor-Immune Cell Interactions in Melanoma and Colon Cancer

The participation of proteasomes in vital cellular and metabolic processes that are involved in tumor growth has made this protease complex an attractive target for cancer treatment. In contrast to ubiquitously available constitutive proteasome, the increased enzymatic activity of immunoproteasome is associated with tumor-infiltrating immune cells, such as antigen-presenting cells and T lymphocytes. In various tumors, an effective anti-tumor immunity is provided through generation of tumor-associated antigens by proteasomes, contributing crucially to cancer eradication by T lymphocytes. The knowledge regarding the role of immunoproteasomes in the communication between tumor cells and infiltrating immune cells is limited. Novel data suggest that the involvement of immunoproteasomes in tumorigenesis is more complex than previously thought. In the intestine, in which diverse signals from commensal bacteria and food can contribute to the onset of chronic inflammation and inflammation-driven cancer, immunoproteasomes exert tumorigenic properties by modulating the expression of pro-inflammatory factors. In contrast, in melanoma and non-small cell lung cancer, the immunoproteasome acts against cancer development by promoting an effective anti-tumor immunity. In this review, we highlight the potential of immunoproteasomes to either contribute to inflammatory signaling and tumor development, or to support anti-cancer immunity. Further, we discuss novel therapeutic options for cancer treatments that are associated with modulating the activity of immunoproteasomes in the tumor microenvironment.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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