乳腺癌干细胞群在不同分子亚型乳腺癌中的作用。

Breast disease Pub Date : 2022-01-01 DOI:10.3233/BD-210050

Parul Gupta, Vikram Singh, Sandeep Kumar, Ashim Das, Gurpreet Singh, Amanjit Bal

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引用次数: 4

摘要

背景:乳腺癌的异质性已被充分证明，在某种程度上归因于癌症干细胞(CSCs)的存在。乳腺癌干细胞是通过细胞表面分子CD44的存在和CD24的缺失来识别的。方法:采用流式细胞术研究CSC表型CD44+/CD24-/low在乳腺癌不同分子亚型中的表达分布，并探讨其与临床病理特征的相关性。结果:在乳腺癌的所有分子亚型中均可见到CSCs。CSCs最多的是luminal B(3.4%)，其次是TNBC(1.7%)和Her-2亚型(1.6%)。CD44+/CD24-细胞数量最少的是Luminal A亚组(1.3%)。结论:肿瘤干细胞在所有亚型中的存在可能提示当前治疗方法在治疗患者时失败的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Breast cancer stem cell population in different molecular subtypes of breast cancer.

Background: Breast cancer heterogeneity is well documented and to some extent is attributed to the presence of cancer stem cells (CSCs). Breast cancer stem cells are identified by the presence of cell surface molecule CD44 and absence of CD24.

Methods: In the present study a flowcytometric analysis was done to study the expression distribution of CSC phenotype of CD44+/CD24-/low, among different molecular subtypes of breast cancer and to find a correlation with clinicopathological features.

Results: CSCs were observed in all the molecular subtypes of breast cancer. The highest population of CSCs was noted in luminal B (3.4%), followed by TNBC (1.7%), and Her-2 subtype (1.6%). The least number of CD44+/CD24- cells were seen in Luminal A subgroup (1.3%).

Conclusion: Existence of cancer stem cells in all the subtypes may suggest the possibility of failure of current therapies in treatment of patients.

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.