Thamiris de Souza, Jessyca Dias Cardoso Monteiro, Cintia Chaves Curioni, Cláudia Cople-Rodrigues, Marta Citelli
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引用次数: 0
摘要
慢性下肢溃疡(LLUs)是指溃疡未能通过有序、及时的治疗过程,形成解剖和功能上的完整性。下肢溃疡会降低患者的生活质量,是一个公共卫生问题。治疗方法包括药物或手术。营养疗法是改善临床症状和LLU愈合的重要辅助手段。考虑到具有抗氧化特性的营养素可改善组织愈合过程,本系统综述旨在通过随机临床试验评估抗氧化营养素补充剂在治疗LLU方面的疗效。本系统综述根据《系统综述和元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-analyses)和《干预措施系统综述科克伦手册》(Cochrane Handbook for Systematic Reviews of Interventions)进行。指导性问题是:抗氧化营养素是否有助于治疗慢性LLU?在搜索与最常见LLU病因相关的抗氧化营养素时,共发现了1184篇文章。在剔除重复文章、局部和/或静脉使用抗氧化剂的研究以及除英语外以其他语言发表的文章后,有14篇文章被纳入本综述。欧米伽-3 脂肪酸、镁、锌、维生素 A、C、D 和白藜芦醇以及益生菌对溃疡愈合有积极的改善作用。如果最初缺乏相应的补充营养素,这些效果会更加明显。因此,纠正和维持充足的营养状况可以改善溃疡愈合,有助于LLU患者的临床治疗。
Nutrients with Antioxidant Properties and Their Effects on Lower-Limb Ulcers: A Systematic Review.
Chronic lower-limb ulcers (LLUs) are ulcers that fail to proceed through an orderly and timely process to produce anatomic and functional integrity. LLUs reduce the quality of life of affected individuals and are a public health problem. The treatment options include medications or surgery. Nutrition therapy is an important adjunct to improve the clinical picture and healing of LLUs. Considering that nutrients with antioxidant properties can improve the process of tissue healing, this systematic review aimed to evaluate the efficacy of antioxidant nutrient supplementation in the treatment of LLUs through randomized clinical trials. This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses and the Cochrane Handbook for Systematic Reviews of Interventions. The guiding question was-can antioxidant nutrients help in the treatment of chronic LLUs? In total, 1184 articles were found when searching for antioxidant nutrients associated with the most common causes of LLUs. Fourteen articles were included in this review after removing duplicates, studies with topical and/or venous use of antioxidants, and articles published in other languages, except English. Omega-3 fatty acids, magnesium, zinc, vitamins A, C, D, and resveratrol along with probiotics positively improved the ulcer healing. These effects were more significant when there was initially a deficiency of the respective supplemented nutrients. Therefore, correcting and maintaining an adequate nutritional status can improve ulcer healing and contribute to the clinical treatment of patients with LLUs.
期刊介绍:
The International Journal of Lower Extremity Wounds (IJLEW) is a quarterly, peer-reviewed journal publishing original research, reviews of evidence-based diagnostic techniques and methods, disease and patient management, and surgical and medical therapeutics for lower extremity wounds such as burns, stomas, ulcers, fistulas, and traumatic wounds. IJLEW also offers evaluations of assessment and monitoring tools, dressings, gels, cleansers, pressure management, footwear/orthotics, casting, and bioengineered skin. This journal is a member of the Committee on Publication Ethics (COPE).