基于社区的前瞻性队列研究酒精-大麻使用与应激事件与临床精神病发生的关系

IF 0.9 4区 医学 Q4 PSYCHIATRY Turk Psikiyatri Dergisi Pub Date : 2021-01-01 DOI:10.5080/u26410
Umut Kirli, Tolga Binbay, Köksal Alptekin, Bülent Kayahan, Hayriye Elbi
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引用次数: 0

摘要

目的:本研究的目的是评估酒精大麻使用和法医/压力事件与随访期间发生临床精神病风险之间的关系。方法:以社区为基础的样本(n: 2142)在基线和随访时筛查临床精神病(精神分裂症和其他精神障碍,具有精神病特征的情感性障碍)。因此,在随访期间发现的偶发临床精神病病例(基线评估时无临床精神病和随访评估时有临床精神病的个体)(n: 27)。这些病例和在随访评估中未报告任何精神病症状的对照组(n: 1691)在随访期间暴露于环境危险因素(总n: 1718)进行比较。结果:在随访期间报告大量饮酒或使用大麻的个体发生临床精神病的风险显着增加。每月饮酒和使用大麻的频率也与风险有关。暴露的压力生活事件越多,发生临床精神病的风险就越高。重度饮酒、大麻使用、应激事件≥3个危险因素共存时,临床精神病发生率明显高于单一危险因素存在时(17.7% vs. 1.6%)。结论:重度饮酒、大麻使用、法医事件和应激事件与临床精神病发生率相关。与滥用酒精/大麻有关的多种压力事件和失调并存,应被视为临床精神病发展的警告。
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The Relationship between Alcohol-Cannabis Use and Stressful Events with the Development of Incident Clinical Psychosis in a Community-Based Prospective Cohort.

Objective: The aim of this study is to evaluate the associations between alcohol-cannabis use and forensic/stressful events with the risk of incident clinical psychosis during follow-up.

Method: A community-based sample (n: 2142) was screened for clinical psychosis (schizophrenia and other psychotic disorders, affective disorders with psychotic features) at baseline and follow-up. Thus, incident clinical psychosis cases to develop during follow-up (individuals with no clinical psychosis at the baseline assessment and with clinical psychosis at the follow-up assessment) were detected (n: 27). These cases and the controls who did not report any psychotic symptoms at the follow-up assessment (n: 1691) were compared for exposure to environmental risk factors during follow-up (total n: 1718).

Results: Individuals reporting heavy alcohol drinking or cannabis use during follow-up had significantly higher risk of incident clinical psychosis. The monthly frequency of drinking and cannabis use was also associated with the risk. Higher number of stressful life events exposed predicted higher risk of incident clinical psychosis. The risk of incident clinical psychosis was significantly higher in case of coexistence of two risk factors (heavy drinking, cannabis use, ≥3 stressful events), in comparison with the existence of a single risk factor (17.7 vs. 1.6%, p<0.001).

Conclusion: Heavy drinking, cannabis use, forensic events and stressful events were associated with the risk of incident clinical psychosis. The coexistence of multiple stressful events and disorders related to abuse of alcohol/cannabis should be considered as a warning for the development of clinical psychosis.

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来源期刊
CiteScore
1.30
自引率
11.10%
发文量
15
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