人类疱疹病毒8阳性弥漫性大b细胞淋巴瘤累及心脏:人类免疫缺陷病毒患者的不寻常表现

Pub Date : 2022-01-17 eCollection Date: 2022-01-01 DOI:10.1155/2022/1298121

Elena M Fenu, Michael W Beaty, Tiffany E O'Neill, Stacey S O'Neill

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引用次数: 2

摘要

人类免疫缺陷病毒（HIV）感染使患者易患淋巴瘤，这既是由于免疫抑制，也是由于与具有致癌潜力的病毒共同感染。人类疱疹病毒8型（HHV8）的共同感染尤其与侵袭性淋巴瘤的发展有关，包括原发性渗出性淋巴瘤和弥漫性大B细胞淋巴瘤（DLBCL）。在此，我们报告了一例不寻常的HHV8阳性DLBCL病例，该病例在尸检中被诊断为长期未经治疗的HIV感染患者，并伴有广泛的心脏受累。

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Cardiac Involvement by Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma: An Unusual Presentation in a Patient with Human Immunodeficiency Virus.

Human immunodeficiency virus (HIV) infection predisposes patients to the development of lymphomas, both due to immune suppression and coinfection with viruses with oncogenic potential. Coinfection with human herpesvirus 8 (HHV8) in particular has been associated with the development of aggressive lymphomas, including primary effusion lymphoma and diffuse large B-cell lymphoma (DLBCL). Herein, we report an unusual case of HHV8-positive DLBCL with extensive cardiac involvement which was diagnosed at autopsy in a patient with long-standing untreated HIV infection.

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