产碳青霉烯酶肠杆菌的流行病学变化。

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Rambam Maimonides Medical Journal Pub Date : 2022-01-27 DOI:10.5041/RMMJ.10461
Khetam Hussein, Yuval Geffen, Orna Eluk, Sigal Warman, Worood Aboalheja, Tamar Alon, Ibrahim Firan, Mical Paul
{"title":"产碳青霉烯酶肠杆菌的流行病学变化。","authors":"Khetam Hussein,&nbsp;Yuval Geffen,&nbsp;Orna Eluk,&nbsp;Sigal Warman,&nbsp;Worood Aboalheja,&nbsp;Tamar Alon,&nbsp;Ibrahim Firan,&nbsp;Mical Paul","doi":"10.5041/RMMJ.10461","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Israeli hospitals were confronted with a major national outbreak of carbapenemase-producing Enterobacterales (CPE) starting in 2006, caused predominantly by monoclonal Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae. Our hospital, Rambam Health Care Campus (RHCC), was one of the medical centers affected by this outbreak. We aimed to investigate the changing epidemiology of CPE at RHCC since 2006.</p><p><strong>Methods: </strong>This was a retrospective observational cohort study performed in Northern Israel (Haifa) at RHCC, which is a primary tertiary acute care academic hospital. The study included all patients who had acquired CPE at RHCC between January 2005 and December 2020.</p><p><strong>Results: </strong>The proportion of patients infected with K. pneumoniae dropped from 100% of all CPE in the first years to 28% (37/134) in 2020. In 2014, the carbapenemase in 94% of all CPE patients (89/95) was KPC. This decreased to 56% in 2020, while New Delhi metallo-β-lactamase (NDM) and OXA-48 carbapenemases increased from 4% and 2% to 29% (39/134) and 12.7% (17/134) of CPE, respectively.</p><p><strong>Conclusions: </strong>The CPE epidemic evolved from KPC-producing K. pneumoniae to involve different Enterobacterales and carbapenemases. Our results are a microcosm of the current global epidemiology attesting to globalization in bacteriology. The results have implications for infection control and antibiotic treatment of CPE infections.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798583/pdf/","citationCount":"2","resultStr":"{\"title\":\"The Changing Epidemiology of Carbapenemase-Producing Enterobacterales.\",\"authors\":\"Khetam Hussein,&nbsp;Yuval Geffen,&nbsp;Orna Eluk,&nbsp;Sigal Warman,&nbsp;Worood Aboalheja,&nbsp;Tamar Alon,&nbsp;Ibrahim Firan,&nbsp;Mical Paul\",\"doi\":\"10.5041/RMMJ.10461\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Israeli hospitals were confronted with a major national outbreak of carbapenemase-producing Enterobacterales (CPE) starting in 2006, caused predominantly by monoclonal Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae. Our hospital, Rambam Health Care Campus (RHCC), was one of the medical centers affected by this outbreak. We aimed to investigate the changing epidemiology of CPE at RHCC since 2006.</p><p><strong>Methods: </strong>This was a retrospective observational cohort study performed in Northern Israel (Haifa) at RHCC, which is a primary tertiary acute care academic hospital. The study included all patients who had acquired CPE at RHCC between January 2005 and December 2020.</p><p><strong>Results: </strong>The proportion of patients infected with K. pneumoniae dropped from 100% of all CPE in the first years to 28% (37/134) in 2020. In 2014, the carbapenemase in 94% of all CPE patients (89/95) was KPC. This decreased to 56% in 2020, while New Delhi metallo-β-lactamase (NDM) and OXA-48 carbapenemases increased from 4% and 2% to 29% (39/134) and 12.7% (17/134) of CPE, respectively.</p><p><strong>Conclusions: </strong>The CPE epidemic evolved from KPC-producing K. pneumoniae to involve different Enterobacterales and carbapenemases. Our results are a microcosm of the current global epidemiology attesting to globalization in bacteriology. The results have implications for infection control and antibiotic treatment of CPE infections.</p>\",\"PeriodicalId\":46408,\"journal\":{\"name\":\"Rambam Maimonides Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2022-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798583/pdf/\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rambam Maimonides Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5041/RMMJ.10461\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rambam Maimonides Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5041/RMMJ.10461","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 2

摘要

目的:2006年起,以色列医院爆发了一场全国性产碳青霉烯酶肠杆菌(CPE)暴发,主要由产碳青霉烯酶肺炎克雷伯菌(KPC)引起。我们的医院,兰巴姆卫生保健校区(RHCC),是受此次疫情影响的医疗中心之一。我们的目的是调查自2006年以来RHCC CPE的流行病学变化。方法:这是一项在以色列北部(海法)RHCC进行的回顾性观察队列研究,RHCC是一家初级三级急性护理学术医院。该研究包括2005年1月至2020年12月期间在RHCC获得CPE的所有患者。结果:肺炎克雷伯菌感染的患者比例从第一年的100%下降到2020年的28%(37/134)。2014年,94%的CPE患者(89/95)的碳青霉烯酶为KPC。到2020年,这一比例降至56%,而新德里金属β-内酰胺酶(NDM)和OXA-48碳青霉烯酶在CPE中的比例分别从4%和2%上升至29%(39/134)和12.7%(17/134)。结论:CPE流行由产kpc肺炎克雷伯菌演变而来,涉及不同肠杆菌和碳青霉烯酶。我们的结果是当前全球流行病学的一个缩影,证明了细菌学的全球化。该结果对CPE感染的感染控制和抗生素治疗具有指导意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The Changing Epidemiology of Carbapenemase-Producing Enterobacterales.

Objective: Israeli hospitals were confronted with a major national outbreak of carbapenemase-producing Enterobacterales (CPE) starting in 2006, caused predominantly by monoclonal Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae. Our hospital, Rambam Health Care Campus (RHCC), was one of the medical centers affected by this outbreak. We aimed to investigate the changing epidemiology of CPE at RHCC since 2006.

Methods: This was a retrospective observational cohort study performed in Northern Israel (Haifa) at RHCC, which is a primary tertiary acute care academic hospital. The study included all patients who had acquired CPE at RHCC between January 2005 and December 2020.

Results: The proportion of patients infected with K. pneumoniae dropped from 100% of all CPE in the first years to 28% (37/134) in 2020. In 2014, the carbapenemase in 94% of all CPE patients (89/95) was KPC. This decreased to 56% in 2020, while New Delhi metallo-β-lactamase (NDM) and OXA-48 carbapenemases increased from 4% and 2% to 29% (39/134) and 12.7% (17/134) of CPE, respectively.

Conclusions: The CPE epidemic evolved from KPC-producing K. pneumoniae to involve different Enterobacterales and carbapenemases. Our results are a microcosm of the current global epidemiology attesting to globalization in bacteriology. The results have implications for infection control and antibiotic treatment of CPE infections.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
期刊最新文献
IgG4-related Breast Disease: Review of the Literature. Inpatient Rehabilitation is Effective for Severe Daily Activity Deficits Related to Chronic Low Back Pain. Kidnapped But Not Kids: A Case Series of Three Octogenarian Hostages Held in Captivity by Hamas. Myxedema Coma-associated Pancytopenia: A Case Report. The Medical Professional Elimination Program and the Ideology and Motivation of Nazi Physicians.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1