SARS-CoV-2疫苗:实体器官移植受者的安全性和免疫原性以及提高疫苗反应的策略

IF 2.4 Q2 SURGERY Current Transplantation Reports Pub Date : 2022-01-01 Epub Date: 2022-01-22 DOI:10.1007/s40472-022-00359-0

Ayelet Grupper, Helena Katchman

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引用次数: 14

摘要

综述目的:虽然实体器官移植(SOT)受者患covid - 19疾病严重并发症和死亡率增加的风险最高，但由于担心免疫介导的不良事件和次优免疫反应，他们接种针对SARS-CoV-2的疫苗仍然具有挑战性。本综述旨在总结目前关于SARS-CoV-2疫苗安全性和有效性的知识，描述与免疫反应相关的因素，并讨论提高SOT受体疫苗免疫原性的策略。最近的发现:SARS-CoV-2疫苗在SOT接受者中是安全的，与排斥反应或其他主要不良事件无关。对两剂疫苗的免疫反应是次优的，并与年龄和免疫抑制程度相关。注射第三剂疫苗可显著增强免疫反应。摘要:本综述加强了现有的建议，即所有SOT受者接种三剂疫苗，并在可能的情况下在移植前完成疫苗接种。

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SARS-CoV-2 Vaccines: Safety and Immunogenicity in Solid Organ Transplant Recipients and Strategies for Improving Vaccine Responses.

Purpose of review: While solid organ transplant (SOT) recipients are at the highest risk for severe complications and increased mortality from COVID19 disease, their vaccination against SARS-CoV-2 remains challenging due to fear of immune-mediated adverse events and suboptimal immune response. Our current review is aimed to summarize current knowledge about the safety and efficacy of SARS-CoV-2 vaccines, describe factors that are correlated with immune response, and discuss strategies to improve vaccine immunogenicity in SOT recipients.

Recent findings: SARS-CoV-2 vaccines are safe in SOT recipients and not related to rejection or other major adverse events. The immune response to two doses of vaccine is suboptimal and correlated to age and magnitude of immunosuppression. Administration of a third vaccine dose brings to significant amplification of immune response.

Summary: This review strengthens the existing recommendation of vaccination by three doses of vaccine in all SOT recipients and completion of vaccination before transplantation if possible.

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来源期刊

Current Transplantation Reports Medicine-Surgery

CiteScore

3.40

自引率

4.80%

发文量

期刊介绍： Under the guidance of Dr. Dorry Segev, from Johns Hopkins, Current Transplantation Reports will provide an in-depth review of topics covering kidney, liver, and pancreatic transplantation in addition to immunology and composite allografts.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of transplantation.