垂体源性糖尿病1例报告。

TouchREVIEWS in endocrinology Pub Date : 2021-04-01 Epub Date: 2021-04-28 DOI:10.17925/EE.2021.17.1.68
Mandeep Singla, Jaspreet Kaur Saini
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引用次数: 1

摘要

我们描述了一例36岁女性因糖尿病酮症酸中毒到急诊科就诊的病例报告。在详细的临床检查中,发现了粗糙的面部特征,如大而多肉的鼻子、厚嘴唇、前突和手脚增厚,提示肢端肥大症。随后,她被诊断为生长激素瘤引起的肢端肥大症。糖耐量受损和糖尿病经常与肢端肥大症有关。持续过量的生长激素会损害胰岛素敏感性,增加糖异生,减少脂肪组织和肌肉中的葡萄糖摄取,并改变胰腺β细胞的功能。如本例所示,糖尿病酮症酸中毒可能是罕见的表现。
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Diabetes Mellitus of Pituitary Origin: A Case Report.

We describe the case report of 36-year-old female who presented to the emergency department with diabetic ketoacidosis. On detailed clinical examination, coarse facial features in the form of large fleshy nose, thick lips, prognathism, and thickening of hands and feet were noticed, suggestive of acromegaly. Subsequently, she was diagnosed with acromegaly due to somatotropinoma. Impaired glucose tolerance and diabetes mellitus are frequently associated with acromegaly. Persistent growth hormone excess impairs insulin sensitivity, increases gluconeogenesis, reduces glucose uptake in adipose tissue and muscle, and alters pancreatic β-cell function. Rarely, diabetic ketoacidosis can be the presenting manifestation, as seen in this case.

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